Gene interactions and pathways from curated databases and text-mining

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RHEB — RPS6KB1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Garami et al., Mol Cell 2003 : Moreover, Rheb overexpression induces S6K1 phosphorylation and inhibits PKB phosphorylation, as do loss-of-function mutations in TSC1/2, but contrary to earlier reports Rheb has no effect on MAPK phosphorylation ... Finally, coexpression of a human TSC2 cDNA harboring a disease associated point mutation in the GAP domain, failed to stimulate Rheb GTPase activity or block Rheb activation of S6K1
Hanrahan et al., Methods Enzymol 2006 : Rheb activation of mTOR and S6K1 signaling