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AKT1 — RHEB

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: AKT1 (AKT1) → RHEB/GTP complex (RHEB) (modification, activates) Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Garami et al., Mol Cell 2003 : Moreover, Rheb overexpression induces S6K1 phosphorylation and inhibits PKB phosphorylation, as do loss-of-function mutations in TSC1/2, but contrary to earlier reports Rheb has no effect on MAPK phosphorylation
McManus et al., EMBO J 2004 (Embryo Loss) : Interestingly, amino acids and Rheb, but not IGF1, activated S6K in the knockin cells, supporting the idea that PtdIns ( 3,4,5 ) P3 stimulates S6K through PKB mediated activation of Rheb