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RET — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → RET (directlyIncreases, STAT3 Activity)
  Evidence: 9083098;11429593;9582023;15592455;12244095;14551213;11850821;9305919

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT3 — RET (physical association, affinity chromatography technology) Yuan et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: STAT3 — RET (physical association, affinity chromatography technology) Hwang et al., Mol Endocrinol 2003*
• IRef Biogrid Interaction: STAT3 — RET (physical association, affinity chromatography technology) Schuringa et al., Oncogene 2001*
• IRef Hprd Interaction: STAT3 — RET (in vitro) Schuringa et al., Oncogene 2001*, Hwang et al., Mol Endocrinol 2003*, Yuan et al., Mol Cell Biol 2004*
• IRef Hprd Interaction: STAT3 — RET (in vivo) Schuringa et al., Oncogene 2001*, Hwang et al., Mol Endocrinol 2003*, Yuan et al., Mol Cell Biol 2004*
• IRef Intact Interaction: STAT3 — RET (association, coimmunoprecipitation) Schuringa et al., Oncogene 2001*

Text-mined interactions from Literome

Schuringa et al., Oncogene 2001 (Cell Transformation, Neoplastic...) : MEN2A-RET induces both Tyr705 and Ser727 phosphorylation of STAT3, and STAT3 serine phosphorylation is required for its maximal transcriptional activity
Hwang et al., Mol Endocrinol 2003 (Carcinoma, Papillary...) : Activation of STAT3 requires the intrinsic kinase activity of RET/PTC ; Janus tyrosine kinase and c-Src kinase are not involved in the RET/PTC mediated activation of STAT3 ... RET/PTC induced activation of STAT3 induces the STAT3-responsive genes, vascular endothelial growth factor, cyclin D1, and intercellular adhesion molecule 1
Kim et al., J Clin Endocrinol Metab 2006 : RET/PTC mediated Y705 phosphorylation of STAT3 was inhibited by addition of SU11248, and the inhibitory effects of SU11248 on the tyrosine phosphorylation and transcriptional activation of STAT3 were very closely correlated with decreased autophosphorylation of RET/PTC
Kim et al., Mol Endocrinol 2007 (Carcinoma, Papillary...) : Thus, this study suggests that LKB1 suppresses tumor growth by inhibiting RET/PTC dependent activation of oncogenic STAT3
Kim et al., BMC cancer 2008 (Carcinoma, Papillary...) : Based on the observation of high levels of PLD expression in human papillary thyroid cancer tissues, we investigated whether PLD plays a role in the regulating the RET/PTC induced STAT3 activation ... Moreover, the RET/PTC mediated transcriptional activation of STAT-3 was synergistically increased by over-expression of PLD, whereas the PLD activity as a lipid hydrolyzing enzyme was not affected by RET/PTC