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MAPK3 — RET
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
De Vita et al., Cancer Res 2000
(MAP Kinase Signaling System...) :
Thus, in PC12 cells, RET-MEN2A associates with the PI3K regulatory subunit p85 and promotes activation of Akt ( also referred to as protein kinase B ) in a PI3K dependent fashion ; in addition,
RET-MEN2A promotes
MAPK activation
Vitagliano et al., Cancer Res 2004
(MAP Kinase Signaling System...) :
Therefore, in thyroid cancer,
RET/PTC mediated
MAPK activation contributes to p27Kip1 deregulation
Mitsutake et al., Endocrinology 2006
(Carcinoma, Papillary...) :
BRAF mediates
RET/PTC induced
mitogen activated protein kinase activation in thyroid cells : functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis ... The requirement for BRAF in
RET/PTC mediated
MAPK activation and gene expression has not been tested functionally ... These data indicate that BRAF is required for
RET/PTC induced
MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs
Sawai et al., Cancer Res 2005
(Adenocarcinoma...) :
The modifying
effect of G691S
RET on GDNF induced invasion and
mitogen activated protein kinase ( MAPK ) signaling was evaluated
Iavarone et al., J Biol Chem 2006
(MAP Kinase Signaling System...) :
Activation of the Erk8
mitogen activated protein ( MAP ) kinase by
RET/PTC3 , a constitutively active form of the RET proto-oncogene
Iervolino et al., Cancer Res 2006
(Cell Transformation, Neoplastic...) :
This results in a significant decrease of
RET induced Shc and
extracellular signal regulated kinase 1/2 phosphorylation levels
Joshi et al., Oncogene 2007
(Adrenal Gland Neoplasms...) :
RET2A mediated regulation of p18 and p27, but not of cyclins D1 and D2,
requires functional
mitogen activated protein kinase signaling
Ledda et al., J Neurosci 2008
:
In particular, we demonstrate that Lrig1 is capable of physically interacting with Ret and that Lrig1/Ret association inhibits GDNF binding, recruitment of
Ret to lipid rafts, receptor autophosphorylation, and mitogen activated protein kinase (
MAPK )
activation in response to GDNF
Takenobu et al., Oncogene 2011
(Neuroblastoma) :
Of note, CD133 related NB cell differentiation and
RET repression were mainly
dependent on
p38MAPK and PI3K/Akt pathways
Kulkarni et al., Mol Oncol 2011
:
We report that
MAPK activation by
RET2A leads to a transient induction of N-Myc mRNA and protein levels, and that N-Myc induction is required to maintain low p18 and p27 levels
Kamijo et al., Pediatr Res 2012
(Neuroblastoma) :
Of note, CD133 related NB cell differentiation and
RET ( rearranged during transfection ) repression were considerably
dependent on
p38MAPK and phosphoinositide 3-kinase (PI3K)/AKT pathways
Song et al., PloS one 2013
:
PRR ( UB-/- ) mice were polyuric, had lower urine osmolality and a higher urine pH following 48 hours of acidic loading with NH4Cl. Taken together, these data show that PRR present in the UB epithelia performs essential functions during UB branching morphogenesis and collecting duct development via control of
Ret/Wnt11 pathway gene expression, UB cell survival,
activation of
Erk1/2 , terminal differentiation and function of collecting duct cells needed for maintaining adequate water and acid-base homeostasis