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MAPK14 — RET
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
De Vita et al., Cancer Res 2000
(MAP Kinase Signaling System...) :
Thus, in PC12 cells, RET-MEN2A associates with the PI3K regulatory subunit p85 and promotes activation of Akt ( also referred to as protein kinase B ) in a PI3K dependent fashion ; in addition,
RET-MEN2A promotes
MAPK activation
Vitagliano et al., Cancer Res 2004
(MAP Kinase Signaling System...) :
Therefore, in thyroid cancer,
RET/PTC mediated
MAPK activation contributes to p27Kip1 deregulation
Mitsutake et al., Endocrinology 2006
(Carcinoma, Papillary...) :
BRAF mediates
RET/PTC induced
mitogen activated protein kinase activation in thyroid cells : functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis ... The requirement for BRAF in
RET/PTC mediated
MAPK activation and gene expression has not been tested functionally ... These data indicate that BRAF is required for
RET/PTC induced
MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs
Sawai et al., Cancer Res 2005
(Adenocarcinoma...) :
The modifying
effect of G691S
RET on GDNF induced invasion and
mitogen activated protein kinase ( MAPK ) signaling was evaluated
Iavarone et al., J Biol Chem 2006
(MAP Kinase Signaling System...) :
Activation of the Erk8
mitogen activated protein ( MAP ) kinase by
RET/PTC3 , a constitutively active form of the RET proto-oncogene
Joshi et al., Oncogene 2007
(Adrenal Gland Neoplasms...) :
RET2A mediated regulation of p18 and p27, but not of cyclins D1 and D2,
requires functional
mitogen activated protein kinase signaling
Ledda et al., J Neurosci 2008
:
In particular, we demonstrate that Lrig1 is capable of physically interacting with Ret and that Lrig1/Ret association inhibits GDNF binding, recruitment of
Ret to lipid rafts, receptor autophosphorylation, and mitogen activated protein kinase (
MAPK )
activation in response to GDNF
Takenobu et al., Oncogene 2011
(Neuroblastoma) :
Of note, CD133 related NB cell differentiation and
RET repression were mainly
dependent on
p38MAPK and PI3K/Akt pathways
Kulkarni et al., Mol Oncol 2011
:
We report that
MAPK activation by
RET2A leads to a transient induction of N-Myc mRNA and protein levels, and that N-Myc induction is required to maintain low p18 and p27 levels
Kamijo et al., Pediatr Res 2012
(Neuroblastoma) :
Of note, CD133 related NB cell differentiation and
RET ( rearranged during transfection ) repression were considerably
dependent on
p38MAPK and phosphoinositide 3-kinase (PI3K)/AKT pathways