Gene interactions and pathways from curated databases and text-mining

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MAPK14 — RET

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

De Vita et al., Cancer Res 2000 (MAP Kinase Signaling System...) : Thus, in PC12 cells, RET-MEN2A associates with the PI3K regulatory subunit p85 and promotes activation of Akt ( also referred to as protein kinase B ) in a PI3K dependent fashion ; in addition, RET-MEN2A promotes MAPK activation
Vitagliano et al., Cancer Res 2004 (MAP Kinase Signaling System...) : Therefore, in thyroid cancer, RET/PTC mediated MAPK activation contributes to p27Kip1 deregulation
Mitsutake et al., Endocrinology 2006 (Carcinoma, Papillary...) : BRAF mediates RET/PTC induced mitogen activated protein kinase activation in thyroid cells : functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis ... The requirement for BRAF in RET/PTC mediated MAPK activation and gene expression has not been tested functionally ... These data indicate that BRAF is required for RET/PTC induced MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs
Sawai et al., Cancer Res 2005 (Adenocarcinoma...) : The modifying effect of G691S RET on GDNF induced invasion and mitogen activated protein kinase ( MAPK ) signaling was evaluated
Iavarone et al., J Biol Chem 2006 (MAP Kinase Signaling System...) : Activation of the Erk8 mitogen activated protein ( MAP ) kinase by RET/PTC3 , a constitutively active form of the RET proto-oncogene
Joshi et al., Oncogene 2007 (Adrenal Gland Neoplasms...) : RET2A mediated regulation of p18 and p27, but not of cyclins D1 and D2, requires functional mitogen activated protein kinase signaling
Ledda et al., J Neurosci 2008 : In particular, we demonstrate that Lrig1 is capable of physically interacting with Ret and that Lrig1/Ret association inhibits GDNF binding, recruitment of Ret to lipid rafts, receptor autophosphorylation, and mitogen activated protein kinase ( MAPK ) activation in response to GDNF
Takenobu et al., Oncogene 2011 (Neuroblastoma) : Of note, CD133 related NB cell differentiation and RET repression were mainly dependent on p38MAPK and PI3K/Akt pathways
Kulkarni et al., Mol Oncol 2011 : We report that MAPK activation by RET2A leads to a transient induction of N-Myc mRNA and protein levels, and that N-Myc induction is required to maintain low p18 and p27 levels
Kamijo et al., Pediatr Res 2012 (Neuroblastoma) : Of note, CD133 related NB cell differentiation and RET ( rearranged during transfection ) repression were considerably dependent on p38MAPK and phosphoinositide 3-kinase (PI3K)/AKT pathways