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AKT1 — RET
Text-mined interactions from Literome
Melillo et al., Oncogene 2001
:
IRS-1 coimmunoprecipitates with Ret and co-expression of IRS-1 results in the potentiation of
Ret mediated activation of
Akt ( PKB ), a bona fide effector of PI3-K ... The deletion of asparagine 1059 ( delN1059 ) and the substitution of leucine 1061 ( L1061P ), two Ret mutations identified in families affected by congenital megacolon ( Hirschsprung 's disease ), impair the binding of IRS-1 to Ret as well as
Ret mediated
Akt ( PKB ) stimulation
Tang et al., Dev Biol 2002
:
Activation of
RET resulted in increased levels of phosphatidylinositol 3-kinase (PI3K) activity and
Akt/PKB phosphorylation
Pelicci et al., Mol Cell Biol 2002
(Multiple Endocrine Neoplasia Type 2a) :
Overexpressed Rai resulted in the potentiation of the
Ret dependent activation of phosphatidylinositol 3-kinase (PI3K) and
Akt
Cuccuru et al., J Natl Cancer Inst 2004
(Carcinoma, Medullary...) :
In TT cells, RPI-1 inhibited proliferation,
Ret tyrosine phosphorylation, Ret protein expression, and the
activation of PLCgamma, ERKs and
AKT
Miyagi et al., Mol Carcinog 2004
(Cell Transformation, Neoplastic...) :
Chronic expression of
RET/PTC 3
enhances basal and insulin stimulated PI3
kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells ... In summary, we have demonstrated that
RET/PTC3 expression enhances basal and insulin stimulated DNA synthesis through PI3 kinase, cooperatively
activates Akt with insulin via PI3 kinase, and preferentially activates the Akt rather than MAP kinase pathway in FRTL-5 cells
Jung et al., Mol Endocrinol 2005
(Carcinoma, Papillary...) :
The
activation of
PKB by
RET/PTC blocked the activity of the forkhead transcription factor, FKHRL1, but a Y315F mutant of PKB failed to inhibit FKHRL1 activity
Zarco et al., Apoptosis 2012
:
We observed, as we have previously described, that the presence of GAS1 reduces
RET phosphorylation and
inhibits the activation of
AKT