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CREB1 — REN
Text-mined interactions from Literome
Germain et al., Biochem J 1996
(Hypertension, Renovascular...) :
Transcriptional induction of the human
renin gene by cyclic AMP
requires cyclic AMP response element binding protein (
CREB ) and a factor binding a pituitary-specific trans acting factor ( Pit-1 ) motif ... Taken together, these results demonstrate that the cAMP response of the human
renin gene may
involve CREB binding the CRE and tissue-specific factors, different from Pit-1, that interact with the Pit-1 response DNA elements
Ying et al., J Biol Chem 1997
:
However, over-expression of
CREB-1 did not significantly
enhance forskolin induced human
renin transcriptional activity
Germain et al., Clin Exp Hypertens 1997
:
Taken together, these results show that the cAMP response of the human
renin gene may
involve CREB binding the CRE and tissue-specific factors ( from chorionic and kidney cell origin ), different from Pit-1, that interact with the Pit-1 response DNA elements