Gene interactions and pathways from curated databases and text-mining

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CREB1 — REN

Text-mined interactions from Literome

Germain et al., Biochem J 1996 (Hypertension, Renovascular...) : Transcriptional induction of the human renin gene by cyclic AMP requires cyclic AMP response element binding protein ( CREB ) and a factor binding a pituitary-specific trans acting factor ( Pit-1 ) motif ... Taken together, these results demonstrate that the cAMP response of the human renin gene may involve CREB binding the CRE and tissue-specific factors, different from Pit-1, that interact with the Pit-1 response DNA elements
Ying et al., J Biol Chem 1997 : However, over-expression of CREB-1 did not significantly enhance forskolin induced human renin transcriptional activity
Germain et al., Clin Exp Hypertens 1997 : Taken together, these results show that the cAMP response of the human renin gene may involve CREB binding the CRE and tissue-specific factors ( from chorionic and kidney cell origin ), different from Pit-1, that interact with the Pit-1 response DNA elements