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CHUK — RELB
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2):
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) complex (CHUK-IKBKG-KPNA3-NFKB1-NFKB2-NFKBIA-NFKBIB-NFKBIE-REL-RELA-RELB-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
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MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I):
TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Corum Interaction:
Complex of 18 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Hprd Interaction:
Complex of 290 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Hprd Interaction:
Complex of 145 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Intact Interaction:
CHUK
—
RELB
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Ophid Interaction:
CHUK
—
RELB
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Demicco et al., Mol Cell Biol 2005
(Breast Neoplasms...) :
Constitutively active
IKKalpha induced p52,
RelB , and cyclin D1 in untransformed mammary epithelial cells
Schneider et al., EMBO J 2006
:
IKKalpha controls
p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression
Yang et al., Am J Respir Cell Mol Biol 2009
(Pneumonia...) :
RelB is differentially
regulated by
IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke ... Transient transfection of dominant negative
IkappaB-kinase-alpha and double mutants of NF-kappaB inducing kinase partially attenuated the CS extract mediated loss of RelB in B cells and normalized the
increased RelB level in macrophages
Baud et al., Med Sci (Paris) 2008
(Lymphoma...) :
It has been shown that this pathway mainly controls the activity of
RelB , a member of the NF-kappaB family, and its activation
requires IKKalpha , one of the two catalytic subunits of the IKK complex
Penzo et al., J Immunol 2010
:
In addition, HMGB1 modestly induces noncanonical
IKKalpha dependent p52 nuclear translocation and
p52/RelB target gene expression