Gene interactions and pathways from curated databases and text-mining

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CXCR4 — RELA

Text-mined interactions from Literome

Kukreja et al., Cancer Res 2005 (Bone Neoplasms...) : We tested the hypothesis that enhanced expression of CXCR4 in prostate cancer cells is dependent upon SDF-1alpha mediated activation of nuclear factor-kappaB (NF-kappaB) ... These data suggest that SDF-1alpha induced expression of CXCR4 in PC-3 cells is dependent on MEK/ERK signaling cascade and NF-kappaB activation
Maroni et al., Carcinogenesis 2007 (Breast Neoplasms...) : HGF induces CXCR4 and CXCL12 mediated tumor invasion through Ets1 and NF-kappaB ... In HGF treated MCF-7 cells, the DNA binding of Ets1 activated by MAPK1/ERK1/2 transduction pathway as well as the DNA binding of NF-kappaB played a critical role in CXCR4 transcription and protein induction
Matteucci et al., Mol Cancer Res 2007 (Breast Neoplasms...) : Thus, the CXCR4 induction by HGF in MCF-7 cells required NF-kappaB and Ets1 activations, downstream of phosphoinositide-3-kinase/Akt, whereas in HGF treated MDA-MB231 cells, HDAC3 activation via c-Src probably caused a reduction of transcription factor activities, such as that of NF-kappaB
Punj et al., Oncogene 2010 (Sarcoma, Kaposi) : Our results show that K13 induced NF-kappaB activity suppresses CXCR4 through upregulation of miR-146a
Rehman et al., Int J Oral Sci 2009 (Carcinoma, Squamous Cell...) : To determine how SDF-1 alpha/CXCR4 activates nuclear factor-kappa B (NF-kappaB) and promotes oral squamous cell carcinoma ( OSCC ) invasion ... We show that the activation of NF-kappaB by CXCR4 occurs through the Carma3/Bcl10/Malt1 (CBM) complex in OSCC ... The CBM complex plays a critical role in CXCR4 induced NF-kappaB activation in OSCC