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CXCR4 — RELA
Text-mined interactions from Literome
Kukreja et al., Cancer Res 2005
(Bone Neoplasms...) :
We tested the hypothesis that enhanced expression of
CXCR4 in prostate cancer cells is
dependent upon SDF-1alpha mediated activation of
nuclear factor-kappaB (NF-kappaB) ... These data suggest that SDF-1alpha induced expression of
CXCR4 in PC-3 cells is
dependent on MEK/ERK signaling cascade and
NF-kappaB activation
Maroni et al., Carcinogenesis 2007
(Breast Neoplasms...) :
HGF
induces CXCR4 and CXCL12 mediated tumor invasion through Ets1 and
NF-kappaB ... In HGF treated MCF-7 cells, the DNA binding of Ets1 activated by MAPK1/ERK1/2 transduction pathway as well as the DNA binding of
NF-kappaB played a critical
role in
CXCR4 transcription and protein induction
Matteucci et al., Mol Cancer Res 2007
(Breast Neoplasms...) :
Thus, the
CXCR4 induction by HGF in MCF-7 cells
required NF-kappaB and Ets1 activations, downstream of phosphoinositide-3-kinase/Akt, whereas in HGF treated MDA-MB231 cells, HDAC3 activation via c-Src probably caused a reduction of transcription factor activities, such as that of NF-kappaB
Punj et al., Oncogene 2010
(Sarcoma, Kaposi) :
Our results show that K13 induced
NF-kappaB activity
suppresses CXCR4 through upregulation of miR-146a
Rehman et al., Int J Oral Sci 2009
(Carcinoma, Squamous Cell...) :
To determine how SDF-1
alpha/CXCR4 activates
nuclear factor-kappa B (NF-kappaB) and promotes oral squamous cell carcinoma ( OSCC ) invasion ... We show that the
activation of
NF-kappaB by
CXCR4 occurs through the Carma3/Bcl10/Malt1 (CBM) complex in OSCC ... The CBM complex plays a critical role in
CXCR4 induced
NF-kappaB activation in OSCC