Gene interactions and pathways from curated databases and text-mining

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CREB1 — RELA

Text-mined interactions from Literome

Delfino et al., J Biol Chem 1999 : Overexpression of NF-kappaB proteins in primary Sertoli and NIH 3T3 fibroblast cells induced the CREB promoter in transient transfection assays ... These data demonstrate that NF-kappaB contributes to the up-regulation of CREB expression in Sertoli cells and raises the possibility that NF-kappaB may induce other Sertoli genes required for spermatogenesis
Pise-Masison et al., Mol Cell Biol 2000 : Analysis of Tax mutants demonstrated that Tax inactivation of p53 function correlates with the ability of Tax to induce NF-kappaB but not p300 binding or CREB transactivation
Jeon et al., Immunopharmacology 2000 : Treatment of DEX to RAW 264.7 cells induced a dose related inhibition of NF-kappaB/Rel and AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor CREB/ATF activation was affected by DEX
Abraham et al., J Immunol 2001 (Endotoxemia...) : In contrast, alpha-adrenergic blockade before endotoxemia was associated with decreased activation of MEK1/2, ERK2, and CREB , but increased activation of NF-kappa B
Don et al., Mol Cell Endocrinol 2002 : In addition, TNFalpha secreted by round spermatids, activates NF-kappaB dependent CREB expression in Sertoli cells and thus, contributes to the elevated CREB levels as long as these cells are intimately associated
Jaramillo et al., J Immunol 2002 (MAP Kinase Signaling System) : Similarly, selective inhibition of cAMP and NF-kappaB strongly down-regulated the induction of all chemokine transcripts as well as CREB and NF-kappaB activation, respectively
Mackenzie et al., FASEB J 2004 : EC, CT, and DP-B inhibited , in vitro, NF-kappaB binding to its DNA consensus sequence, but they had no effect on the binding activity of CREB or OCT-1
Kaltschmidt et al., Mol Cell Biol 2006 (Synaptic Transmission) : Consequently, NF-kappaB inhibition led to a decrease in forskolin induced CREB phosphorylation
Zuscik et al., Environ Health Perspect 2007 : Although Pb had no effect on basal CREB or Wnt/beta-catenin pathway activity, it induced NFkappaB signaling and inhibited AP-1 signaling
Deree et al., Clinics (Sao Paulo) 2008 (Sepsis) : The increased level of cAMP that results from phosphodiesterase inhibition affects cytoplasmic and nuclear events, resulting in the attenuation of NF-kB and the activation of CREB transcriptional DNA binding through pathways that are partially Protein kinase A-independent
Yao et al., J Neurosci 2009 : Blocking TRPC channels and specific downregulation of TRPC channels 1 and 5 resulted in suppression of CCL2 induced ERK/CREB activation but not Akt/NF-kappaB activation
Parry et al., J Immunol 1997 : These results suggest that activation of the protein kinase A pathway inhibits NF-kappaB transcription by phosphorylating CREB , which competes with p65 for limiting amounts of CBP