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IL12A — REL

Text-mined interactions from Literome

Grumont et al., J Exp Med 2001 : This data establishes the IL-12 p35 gene as a new target of c-Rel and shows that the regulation of IL-12 p70 expression at the transcriptional level by Rel/NF-kappaB is controlled through both the p35 and p40 genes in a cell type-specific fashion
Mason et al., J Immunol 2002 (Inflammation...) : Recent studies have shown that c-Rel , a member of the NF-kappaB family of transcription factors, is essential for LPS induced IL-12p40 production by macrophages ... In this study, we demonstrate that c-Rel is also required for IL-12p40 production by macrophages in response to Corynebacterium parvum, CpG oligodeoxynucleotides, anti-CD40 and low molecular weight hyaluronic acid ... Furthermore, c-Rel was not required for IL-12p40 production by macrophages or dendritic cells in response to soluble Toxoplasma Ag, and neutrophils from c-Rel ( -/- ) mice contain normal amounts of preformed IL-12p40
Mason et al., J Immunol 2004 (Toxoplasmosis, Animal) : For example, c-Rel is essential for the production of IL-12 in response to LPS, but dispensable for IL-12 production in response to Toxoplasma Ag
Filipe-Santos et al., J Exp Med 2006 (Genetic Predisposition to Disease...) : IL-12 production was also impaired as the result of a specific defect in NEMO- and NF-kappaB/c-Rel mediated CD40 signaling after the stimulation of monocytes and dendritic cells by CD40L expressing T cells and fibroblasts, respectively ... They also demonstrate the importance of the T cell- and CD40L triggered, CD40-, and NEMO/NF-kappaB/c-Rel mediated induction of IL-12 by monocyte derived cells for protective immunity to mycobacteria in humans
Wang et al., J Immunol 2008 (Chronic Disease...) : The NF-kappaB subunit c-Rel can regulate expression of IL-12/23 subunits suggesting that it could have a critical role in mediating the development of chronic inflammation within the lower bowel
Kortylewski et al., Cancer Cell 2009 (Neoplasms) : Furthermore, Stat3 inhibits NF-kappaB/c-Rel dependent IL-12/p35 gene expression in tumor associated dendritic cells
Nedjai et al., Cell Immunol 2011 (Hereditary Autoinflammatory Diseases) : Interestingly, high p65 activity was associated with elevated IL-8 secretion, whereas high c-Rel activity increased IL-1ß and IL-12 secretion
Visekruna et al., Clin Dev Immunol 2012 : Additionally, c-Rel dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T-cell differentiation and effector functions
Gri et al., J Biol Chem 1998 (Cell Transformation, Viral) : Transient expression of Ets-2 and c-Rel in B, T, and monocytic cell lines synergistically activated the IL-12 p40 promoter, apparently overcoming the requirement for cell type- or stimulant-specific transcription factors