Gene interactions and pathways from curated databases and text-mining

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CHUK — REL

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Silverman et al., Genes Dev 2000 : Remarkably, this Drosophila IkappaB kinase complex is not required for the activation of the Rel proteins Dif and Dorsal through the Toll signaling pathway, which is essential for antifungal immunity and dorsoventral patterning during early development ... Thus, a yet to be identified IkappaB kinase complex must be required for Rel protein activation via the Toll signaling pathway
Weber et al., Gastroenterology 2000 : NF-kappaB/Rel activity induced by tumor necrosis factor alpha, 12-O-tetradecanoylphorbol-13-acetate, or overexpression of NF-kappaB inducing kinase, IKK-alpha, IKK-beta , or constitutively active IKK-alpha and IKK-beta mutants was inhibited dose dependently by sulfasalazine
Hansberger et al., J Virol 2007 : Collectively, these findings indicate a novel pathway of NF-kappaB/Rel activation involving IKKalpha and IKKgamma/Nemo, which together mediate the expression of downstream proapoptotic genes in reovirus infected cells
Garbati et al., Gene Expr 2008 : Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro : evidence that IKK does not directly enhance GAL4-REL transactivation ... We also show that the previously reported effects of overexpressed IKK and tumor necrosis factor treatment on GAL4-REL transactivation are due to IKK mediated activation of the endogenous NF-kappa B pathway, which increases transcription from kappa B sites in the promoter of a commonly used GAL4 expression vector