Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RB1
→
NF1
(decreases, NF1 Activity)
Evidence: loss of neurofibromin induced the accumulation of p53 and the activation of Rb, as demonstrated by reduced levels of hyperphosphorylated Rb (Figure 2A).
OpenBEL Selventa BEL large corpus:
RB1
→
NF1
(decreases)
Evidence: Importantly, GRD expression resulted in the activation of both the Rb and p53 pathways (Figure 3D), and the same cell cycle inhibitors were upregulated in human cells treated with NF1- specific shRNA constructs (Figure 3F), with the exception of p16, which was only activated in NF1KD- and not GRD-expressing cells.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *