Gene interactions and pathways from curated databases and text-mining

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CASP7 — RASA1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wen et al., Cell Death Differ 1998 : Our results demonstrate that diverse apoptotic stimuli cause caspase mediated cleavage of rasGAP early in apoptosis
Yang et al., Eur Cytokine Netw 2002 (MAP Kinase Signaling System) : However, low caspase activity readily induces the cleavage of RasGAP into an N-terminal fragment that generates potent anti-apoptotic signals
Michod et al., Mol Cancer Res 2007 (MAP Kinase Signaling System...) : TAT-RasGAP ( 317-326 ) did not affect PUMA levels, however, but increased genotoxin induced mitochondrial depolarization and caspase-3 activation