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RAF1 — TPO

Text-mined interactions from Literome

Dorsch et al., J Exp Med 1997 : This mutant still mediates TPO induced phosphorylation of Shc, Vav, mitogen activated protein kinase ( MAPK ) and Raf-1 as well as induction of c-fos and c-myc, although at somewhat reduced levels
Ezumi et al., Eur J Biochem 1998 : TPO did not activate the mitogen activated protein kinase/ERK kinases, MEK1 and MEK2, but activated Raf-1 and directly augmented the PKC mediated MEK activation, suggesting that TPO primarily potentiates the ERK pathway through regulating MEKs or upstream steps of MEKs including Raf-1