Gene interactions and pathways from curated databases and text-mining

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EPO — RAF1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RAF1 → EPO (increases)
    Evidence: Y341 is phosphorylated by the Src family of non-RTKs, Janus kinase, and erythropoietin.

Text-mined interactions from Literome

Tilbrook et al., Arch Biochem Biophys 2001 (Leukemia, Erythroblastic, Acute) : Erythropoietin stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells ... Here we used the J2E erythroid cell line transformed by the nu-raf/nu-myc oncogenes to examine the effects of erythropoietin on endogenous Raf-1 activity
Chen et al., Blood 2004 : Erythropoietin regulation of Raf-1 and MEK : evidence for a Ras independent mechanism ... We now show that EPO induces phosphorylation of Raf-1 at serine 338 and within the carboxy-terminal domain, resulting in an electrophoretic mobility change ( hyperphosphorylation )
Carroll et al., J Biol Chem 1991 : Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin mediated proliferation ... Erythropoietin mediates the rapid phosphorylation of Raf-1 in the murine cell lines HCD-57 and FDC-P1/ER, which proliferate in response to this cytokine ... Furthermore, in association with Raf-1 phosphorylation, erythropoietin induces a 2-3-fold increase in Raf-1 kinase activity as measured in immune complex kinase assays in vitro
Todokoro et al., Biochem Biophys Res Commun 1994 : We show here that binding of erythropoietin to its receptor induced activation of protein tyrosine kinases including Jak2, and of Ras, Raf-1 , mitogen activated protein ( MAP ) kinase kinase and MAP kinases ( ERK1 and ERK2 )
Barber et al., Blood 1997 : Erythropoietin activates Raf1 by an Shc independent pathway in CTLL-EPO-R cells
Devemy et al., Cell Signal 1997 : Activation of Raf-1 and mitogen activated protein kinases by erythropoietin and inositolphosphate-glycan in normal erythroid progenitor cells : involvement of protein kinase C ... In this work, we show that erythropoietin and inositolphosphate-glycan activate Raf-1 and the mitogen activated protein kinases ( MAP kinases ) in normal erythropoietin-responsive cells ... Using a protein kinase C ( PKC ) activator such as the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate and the PKC inhibitor GF109203X, we investigated a possible involvement of PKC during activation of Raf-1 and MAP kinase by erythropoietin or inositolphosphate-glycan ... These results support the hypothesis that erythropoietin and inositolphosphate-glycan activate Raf-1 and MAP kinases in normal erythroid progenitor cells and suggest that this activation involves PKC