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EPO — RAF1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
RAF1
→
EPO
(increases)
Evidence: Y341 is phosphorylated by the Src family of non-RTKs, Janus kinase, and erythropoietin.
Text-mined interactions from Literome
Tilbrook et al., Arch Biochem Biophys 2001
(Leukemia, Erythroblastic, Acute) :
Erythropoietin stimulated
Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells ... Here we used the J2E erythroid cell line transformed by the nu-raf/nu-myc oncogenes to examine the
effects of
erythropoietin on endogenous
Raf-1 activity
Chen et al., Blood 2004
:
Erythropoietin regulation of
Raf-1 and MEK : evidence for a Ras independent mechanism ... We now show that
EPO induces phosphorylation of
Raf-1 at serine 338 and within the carboxy-terminal domain, resulting in an electrophoretic mobility change ( hyperphosphorylation )
Carroll et al., J Biol Chem 1991
:
Erythropoietin induces
Raf-1 activation and Raf-1 is required for erythropoietin mediated proliferation ...
Erythropoietin mediates the rapid phosphorylation of
Raf-1 in the murine cell lines HCD-57 and FDC-P1/ER, which proliferate in response to this cytokine ... Furthermore, in association with Raf-1 phosphorylation,
erythropoietin induces a 2-3-fold increase in
Raf-1 kinase activity as measured in immune complex kinase assays in vitro
Todokoro et al., Biochem Biophys Res Commun 1994
:
We show here that binding of
erythropoietin to its receptor
induced activation of protein tyrosine kinases including Jak2, and of Ras,
Raf-1 , mitogen activated protein ( MAP ) kinase kinase and MAP kinases ( ERK1 and ERK2 )
Barber et al., Blood 1997
:
Erythropoietin activates
Raf1 by an Shc independent pathway in CTLL-EPO-R cells
Devemy et al., Cell Signal 1997
:
Activation of
Raf-1 and mitogen activated protein kinases by
erythropoietin and inositolphosphate-glycan in normal erythroid progenitor cells : involvement of protein kinase C ... In this work, we show that
erythropoietin and inositolphosphate-glycan
activate Raf-1 and the mitogen activated protein kinases ( MAP kinases ) in normal erythropoietin-responsive cells ... Using a protein kinase C ( PKC ) activator such as the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate and the PKC inhibitor GF109203X, we investigated a possible involvement of PKC during
activation of
Raf-1 and MAP kinase by
erythropoietin or inositolphosphate-glycan ... These results support the hypothesis that
erythropoietin and inositolphosphate-glycan
activate Raf-1 and MAP kinases in normal erythroid progenitor cells and suggest that this activation involves PKC