◀ Back to IGF1
IGF1 — RAD50
Text-mined interactions from Literome
Tamburini et al., Blood 2008
(Leukemia, Myeloid, Acute) :
This mTOR C1-mediated Akt up-regulation was explained by an insulin-like growth factor-1 (IGF-1)/IGF-1 receptor autocrine loop : ( 1 ) blast cells expressed functional
IGF-1 receptors, and IGF-1 induced Akt activation was
increased by
RAD001 , ( 2 ) a neutralizing anti-IGF-1R alpha-IR3 monoclonal antibody reversed the RAD001 induced Akt phosphorylation, and ( 3 ) autocrine production of IGF-1 was detected in purified blast cells by quantitative reverse transcription-polymerase chain reaction and immunofluorescence
Moore et al., Blood 2013
(Thrombocythemia, Essential) :
Indeed, we found that platelets from JAK2V617F positive ET patients have significantly reduced phosphorylation of the PI3 kinase substrate Akt, and have reduced activation of
Rap1 in
response to thrombopoietin,
IGF-1 , ADP, SFLLRN, and thrombin