Gene interactions and pathways from curated databases and text-mining

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MAPK14 — RAC2

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 → MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 (activation)

Text-mined interactions from Literome

Mainiero et al., Immunity 2000 (MAP Kinase Signaling System) : Finally, we provide direct evidence that p95 Vav and Rac control the activation of p38 MAPK triggered by beta1 integrins
Versteeg et al., J Biol Chem 2000 : In turn Rac mediates p38 mitogen activated protein ( MAP ) kinase activation and cytoskeletal reorganization, whereas factor VIIa induced p42/p44 MAP kinase stimulation required PI3K enzymatic activity but was not inhibited by dominant negative Rac proteins
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : Rac and Cdc42, but not Ras or Rho, were responsible for this MAPK/ERK activation ... We conclude from these data that Rac/Cdc42 dependent activation of MAPK/ERK is a critical event in the immediate phagocytic response of PMNs to microbial challenge
Chen et al., Mol Microbiol 2004 (MAP Kinase Signaling System) : Co-expression of DARas with dominant active Rac ( DARac ) stimulates MAPK activation and restores the wild-type phenotype
Nishida et al., J Biol Chem 2005 : Dominant negative Rac inhibited angiotensin II-stimulated ROS production, JNK activation, and p38 MAPK activation but did not affect ERK activation
Otis et al., Mol Cell Endocrinol 2007 : The increase in cell protein content induced by Ang II entails formation of a cortical actin ring and Rac dependent activation of p42/p44(mapk) and p38 MAPK