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AKT1 — RAC2
Text-mined interactions from Literome
Yang et al., Immunity 2000
:
Rac2 stimulates
Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
Genot et al., Mol Cell Biol 2000
:
Similar to TCR stimulation,
L61Rac induced
Akt/PKB kinase activity is also LY294002 and wortmannin sensitive ... Similar to TCR stimulation,
L61Rac induced
Akt/PKB kinase activity is also LY294002 and wortmannin sensitive
Djouder et al., J Immunol 2001
(Calcium Signaling) :
Rac and phosphatidylinositol 3-kinase
regulate the
protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells ... Our results indicate that in rat basophilic leukemia cells
Rac and PI3-kinase
regulate PKB and suggest that Rac is functionally located upstream and/or parallel of PI3-kinase/PKB in FcepsilonRI signaling
Sánchez-Martín et al., J Biol Chem 2004
:
We have identified Vav, a guanine nucleotide exchange factor for Rac-1, and PI3K/Akt, as regulators of the activation and inactivation phases of the activity of Rac-1, respectively, in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and
PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1, ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant
blocks LFA-1 mediated
Rac activation, ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity, and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited, respectively, Rac-1 activity
Fukuyama et al., Biochem Biophys Res Commun 2004
:
Dominant negative
Rac severely inhibited PDGF induced osteoblast migration and
reduced Akt phosphorylation
Goparaju et al., Mol Cell Biol 2005
:
Although S1P(2) deletion had no significant effect on tyrosine phosphorylation of the PDGF receptors or activation of extracellular signal regulated kinase 1/2 or
Akt induced by PDGF, it reduced sustained PDGF dependent p38 phosphorylation and markedly
enhanced Rac activation
Lee et al., Histochem Cell Biol 2006
:
In this report, we describe that S1P stimulated cortactin translocation to the cell periphery to form lamellipodia is specifically mediated by the endothelial S1P1 G-protein coupled receptor, and is regulated by G ( i ) -mediated
Akt dependent S1P1 receptor phosphorylation and
Cdc42/Rac activation pathways
Morley et al., Cell Signal 2007
(Cell Transformation, Neoplastic) :
We found that Dbl
induced the phosphorylation of
Akt on threonine 308, through the GTPases
Rac and Cdc42 and in a PI3-kinase dependent manner
Zhou et al., J Biol Chem 2006
:
Opposing
roles for
Akt1 and Akt2 in
Rac/Pak signaling and cell migration
JeBailey et al., Diabetes 2007
(Insulin Resistance) :
Small interfering RNA dependent Rac1 knockdown prevented actin remodeling and GLUT4 translocation but spared Akt phosphorylation, suggesting that
Rac and actin remodeling do not
contribute to overall
Akt activation
Chaigne-Delalande et al., Oncogene 2008
:
Constitutively active
Rac stimulates
Akt activity in T lymphocytes cultured in suspension ... We now show that
V12Rac mediated stimulation of
Akt is not restricted to the hematopoietic lineage but is dependent on the adherence status of the cell ...
V12Rac mediated stimulation of
Akt as well as molecular association between Rac and Akt occurred exclusively in cells kept in suspension
Miranti et al., Curr Biol 1998
:
This pathway may regulate multiple downstream events in hematopoietic cells, including
Rac induced lamellipodia formation, tyrosine phosphorylation of Cbl, and activation of JNK, ERK2 and the phosphatidylinositol 3'-kinase regulated kinase
Akt
Nishida et al., Oncogene 1999
:
Furthermore, the serine/threonine kinase
Akt was
stimulated by activated
Rac and fetal bovine serum in a synergistic manner