Nakamura et al., J Heart Lung Transplant 2004
:
Inhibition of NOS by L-NAME resulted in a significant ( p < 0.01 ) increase in PVR ( DeltaPVR : 0.110 +/- 0.012 cm H ( 2 ) O/ml. min ) within 5 minutes
Gordon et al., J Appl Physiol 1993
(Anoxia) :
To determine whether endothelium derived nitic oxide ( EDNO ), like dilator prostaglandins, attenuates pulmonary vasomotor tone more in younger than in older newborns, we examined the effects of a nitric oxide synthase inhibitor, N omega-nitro-L-arginine ( L-NA ), on total and segmental pulmonary vascular resistance (PVR) in isolated blood perfused cyclooxygenase inhibited lungs of < 2-day-old ( 2D ) and 1-mo-old ( 1M ) lambs