Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PTPRC

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → PTPRC (decreases, PTPRC Activity, MAPK3 Activity) Deszo et al., J Biol Chem 2001*
    Evidence: reduction in CD45 expression caused the duration of peak PMA-induced MEK and extracellular signal-regulated kinase (ERK) 1/2 activity to increase from 5 min to 30 min while leading to a 4-fold increase in PMA-dependent PKCdelta activation.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *