Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PTPN21

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → PTPN21 (increases, PTPN21 Activity, MAPK3 Activity) Cardone et al., Mol Cell Biol 2004*
    Evidence: PTPD1 activates src tyrosine kinase and increases the magnitude and duration of epidermal growth factor (EGF) signaling. EGF receptor phosphorylation and downstream activation of ERK 1/2 and Elk1-dependent gene transcription are enhanced by PTPD1.