Gene interactions and pathways from curated databases and text-mining

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IGF1 — PTPN1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Buckley et al., Mol Cell Biol 2002 : Coexpression of PTP-1B with a beta-chain construct of the IGF-IR ( betaWT ) inhibited IGF-IR kinase activity in fission yeast Schizosaccharomyces pombe, in COS cells, and in IGF-IR-deficient fibroblasts ... These findings demonstrate that PTP-1B can regulate IGF-IR kinase activity and function and that loss of PTP-1B can enhance IGF-I mediated cell survival, growth, and motility in transformed cells
Arroba et al., Invest Ophthalmol Vis Sci 2013 (Disease Models, Animal...) : Although loss of PTP1B enhances tyrosine phosphorylation of the IGF-IR in retinal explants of IRS2 ( -/- ) mice, Akt activation remains defective owing to elevated PTEN levels and, thus, structural and functional visual defects persist in this model