◀ Back to IGF1
IGF1 — PTPN1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IGF1 pathway:
PTP1B (PTPN1)
→
IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1)
(modification, collaborate)
Buckley et al., Mol Pathol 2002*, Blanquart et al., Mol Pharmacol 2005*
Evidence: expresssion pattern, mutant phenotype, physical interaction
-
NCI Pathway Database IGF1 pathway:
PTP1B (PTPN1)
→
IGF-1R heterotetramer/IGF1/PTP1B complex (IGF1R-IGF1-PTPN1)
(modification, collaborate)
Buckley et al., Mol Pathol 2002*, Blanquart et al., Mol Pharmacol 2005*
Evidence: expresssion pattern, mutant phenotype, physical interaction
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1 complex (IGF1R-IGF1)
→
IGF-1R heterotetramer/IGF1/PTP1B complex (IGF1R-IGF1-PTPN1)
(modification, collaborate)
Buckley et al., Mol Pathol 2002*, Blanquart et al., Mol Pharmacol 2005*
Evidence: expresssion pattern, mutant phenotype, physical interaction
Text-mined interactions from Literome
Buckley et al., Mol Cell Biol 2002
:
Coexpression of
PTP-1B with a beta-chain construct of the IGF-IR ( betaWT )
inhibited IGF-IR kinase activity in fission yeast Schizosaccharomyces pombe, in COS cells, and in IGF-IR-deficient fibroblasts ... These findings demonstrate that PTP-1B can regulate
IGF-IR kinase activity and function and that loss of
PTP-1B can
enhance IGF-I mediated cell survival, growth, and motility in transformed cells
Arroba et al., Invest Ophthalmol Vis Sci 2013
(Disease Models, Animal...) :
Although loss of
PTP1B enhances tyrosine phosphorylation of the
IGF-IR in retinal explants of IRS2 ( -/- ) mice, Akt activation remains defective owing to elevated PTEN levels and, thus, structural and functional visual defects persist in this model