Gene interactions and pathways from curated databases and text-mining

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AKT1 — PTPN1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Egawa et al., J Biol Chem 2001 (Carcinoma, Hepatocellular...) : These effects were specific for insulin signaling, because platelet derived growth factor ( PDGF ) -stimulated PDGF receptor tyrosine phosphorylation and Akt phosphorylation were not inhibited by PTP1B overexpression ... In both cells, PTP1B overexpression blocked insulin stimulated tyrosine phosphorylation of the insulin receptor and IRS-1 by more than 70 % and resulted in a significant inhibition of the association between IRS-1 and the p85 subunit of phosphatidylinositol 3-kinase and Akt phosphorylation as well as mitogen activated protein kinase phosphorylation
Shimizu et al., Endocrinology 2002 : Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen activated protein kinase in 3T3-L1 adipocytes
Clampit et al., Biochem Biophys Res Commun 2003 (Carcinoma, Hepatocellular) : Reduction of PTP1B expression in FAO cells also caused an increase in insulin stimulated phosphorylation of PKB and GSK3, without any change in protein expression
Vercauteren et al., Circulation 2006 (Cardiac Output, Low) : PTP1B inhibition stimulated early eNOS phosphorylation and increased phosphorylation of Akt
Venkatesan et al., FASEB J 2008 : Interestingly, resveratrol increased the activity of protein tyrosine phosphatase PTP1B , which dephosphorylates PDGF stimulated phosphorylation at tyrosine-751 and tyrosine-716 on PDGFR with concomitant reduction in Akt and Erk1/2 kinase activity
González-Rodríguez et al., Diabetes 2010 : The absence of PTP1B in the double-mutant mice restored hepatic IRS1 mediated phosphatidylinositol (PI) 3-kinase/Akt/Foxo1 signaling
Chen et al., Biochem Biophys Res Commun 2010 (Hyperglycemia...) : Here we report that BBR mimics insulin action by increasing glucose uptake ability by 3T3-L1 adipocytes and L6 myocytes in an insulin independent manner, inhibiting phosphatase activity of protein tyrosine phosphatase 1B (PTP1B) , and increasing phosphorylation of IR, IRS1 and Akt in 3T3-L1 adipocytes
Wang et al., Med Oncol 2012 (Disease Progression...) : Overexpression of PTP1B promoted the proliferation and in vivo tumorigenesis of MKN45 cells and also increased the phosphorylation levels of Akt , Erk1/2, and FAK and the activity of Src
Stull et al., Diabetes 2012 (Diabetes Mellitus, Type 2...) : PTP1B overexpression resulted in reduction of Akt phosphorylation in the control subjects