Gene interactions and pathways from curated databases and text-mining

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AKT1 — PTK6

Text-mined interactions from Literome

Kue et al., J Urol 2000 (Prostatic Neoplasms) : Whereas activation of Akt by these stimuli is not dependent on protein tyrosine kinase activation, it is mediated by PI3K
Sengupta et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System...) : PTK787 inhibited the VEGF induced activation of Akt and ERKs, without affecting the HGF/SF induced phosphorylation
Haegebarth et al., Mol Cell Biol 2006 : It was previously shown that the serine threonine kinase Akt is a substrate of PTK6 and that PTK6 mediated phosphorylation of Akt on tyrosine resulted in inhibition of Akt activity
Mehdi et al., Biochemistry 2006 : Since BMOV is an inhibitor of protein tyrosine phosphatases and through enhanced tyrosine phosphorylation may activate various protein tyrosine kinases ( PTK ), we have investigated the potential role of different receptor or nonreceptor PTK in mediating BMOV induced PKB phosphorylation
Liu et al., Lab Invest 2009 (Disease Models, Animal...) : PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of cyclin D1 and cyclin E. PTK/ZK significantly inhibited vascular endothelial growth factor ( VEGF ) expression, as well as VEGF simulated cell proliferation and phosphorylation of Akt in activated HSCs
Liu et al., Lab Invest 2009 (Liver Cirrhosis) : We provide evidence that PTK787/ZK222584 ( PTK/ZK ) , a potent tyrosine kinase inhibitor that blocks vascular endothelial growth factor receptor ( VEGFR ), significantly inhibits PDGF receptor expression, as well as PDGF simulated HSC proliferation, migration and phosphorylation of ERK1/2, Akt and p70S6 kinase
Zheng et al., Mol Cell Biol 2010 : Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor ... Our data indicate that in addition to promoting growth factor receptor mediated activation of AKT, PTK6 can directly activate AKT to promote oncogenic signaling
Zheng et al., Oncogene 2013 (Cell Transformation, Neoplastic...) : Expression of FAK and Palm-PTK6-YF in Fak-/- MEFs synergistically activates AKT and protects cells against anoikis
Weidenaar et al., Mol Cancer Res 2013 (Leukemia, Myeloid, Acute...) : Proteome profiler array analysis of downstream kinases revealed that PTK/ZK reduced activation of PI3K/Akt kinase signaling