Gene interactions and pathways from curated databases and text-mining

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CREB1 — PTK2

Text-mined interactions from Literome

Hisaoka et al., Brain Res 2008 (Glioma) : The amitriptyline induced phosphorylation of CREB was completely blocked by U0126 [ a mitogen activated protein ( MAP) kinase kinase 1 inhibitor ] and genistein ( a PTK inhibitor ), but not by inhibitors of protein kinase A, p38 MAP kinase, or Ca ( 2+ ) /calmodulin dependent kinase
Guyot et al., Immunology 1998 : Phosphorylation of CREB occurred through a herbimycin A and Rp-cAMP-sensitive pathway, suggesting phosphorylation required antecedent activation of both protein tyrosine kinases ( PTK ) and protein kinase A (PKA)