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MAPK14 — PTHLH
Text-mined interactions from Literome
Miao et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
PTHrP increased
mitogen activated protein kinase ( MAPK ) activity in BMC and MAPK activity, and PTHrP induced osteogenic cell proliferation could be blocked by the MEK inhibitor PD-098059 ... Although wortmannin and H8, inhibitors of phosphoinositol 3-kinase and protein kinase A, respectively, did not block
PTHrP stimulated Ras or
MAPK activity, chelerythrin chloride, a known protein kinase C inhibitor, did block these PTHrP actions as well as PTHrP induced osteogenic cell proliferation
Chan et al., Endocrinology 2001
:
These results indicate that
PTHrP can
increase MAPK activity in 3T3-L1 cells via the PKA pathway, thereby enhancing PPAR gamma phosphorylation
Chen et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
PTHrP mediated down-regulation of PTH-1R mRNA and up-regulation of c-fos mRNA were MAPK independent, whereas
PTHrP stimulation of fra-2 and interleukin-6 (IL-6) mRNA was
MAPK dependent
Ortega et al., Clin Sci (Lond) 2007
(Myocardial Infarction) :
Moreover, 10 ( -7 ) mol/l
PTHrP- ( 1-36 )
increased ( 2-fold over control )
MAPK activation in human platelets