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IGF2 — PTH
Text-mined interactions from Literome
Pereira et al., Endocrinology 1999
:
PTH induces the synthesis of insulin-like growth factor I (IGF-I) and
regulates the expression of
IGF binding proteins ( IGFBP ) in osteoblast cultures
Erclik et al., J Mol Endocrinol 2005
(Osteosarcoma) :
Activation of the
insulin-like growth factor binding protein-5 promoter by
parathyroid hormone in osteosarcoma cells requires activation of an activated protein-2 element
Wang et al., J Endocrinol 2006
:
However,
PTH increased the mRNA levels of IGF-I and
IGF-IR only in the bones of male mice
Tørring et al., Endocrinology 1991
:
Taken with the known
effects of
PTH on
IGF production in bone cells, the data suggest that PTH and PTHrP may modulate local IGF action in bone through the regulation of specific IGFBP availability
Linkhart et al., Endocrinology 1991
(Bone Resorption) :
In a previous study we found that
PTH stimulated bone resorption and release of insulin-like growth factor-I (IGF-I) and
IGF-II from cultured neonatal mouse calvaria ... The results of this and the previous study suggest that
PTH , TGF beta, and 1,25- ( OH ) 2D3 differentially
regulate mouse calvarial cell IGF-I and
IGF-II production
Linkhart et al., Endocrinology 1989
:
Calcitonin inhibited PTH stimulated resorption, but had no effect on PTH stimulation of IGF-I and IGF-II release, suggesting that
PTH effects on IGF-I and
IGF-II release were not dependent on resorption
Nasu et al., FEBS Lett 1997
:
Stimulatory
effects of
parathyroid hormone and 1,25-dihydroxyvitamin D3 on
insulin-like growth factor binding protein-5 mRNA expression in osteoblastic UMR-106 cells : the difference between transient and continuous treatments
McCarthy et al., J Biol Chem 1997
:
In osteoblasts,
IGF-I synthesis is
enhanced by
parathyroid hormone and prostaglandin E2 ( PGE2 ) through cAMP activated protein kinase