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IGF1 — PTH

Text-mined interactions from Literome

Pereira et al., Endocrinology 1999 : PTH induces the synthesis of insulin-like growth factor I (IGF-I) and regulates the expression of IGF binding proteins ( IGFBP ) in osteoblast cultures ... PTH induces the synthesis of insulin-like growth factor I (IGF-I) and regulates the expression of IGF binding proteins ( IGFBP ) in osteoblast cultures
Harvey et al., J Biol Chem 1999 : Collectively, our results indicate that the effect of PTH may be mediated at least in part through the regulation of the IGF/IGFBP axis, by a decrease in the level of IGFBP-3, and an increase in free IGF-I levels
Billiard et al., J Biol Chem 2001 : Prostaglandin E2 ( PGE2 ) and parathyroid hormone enhance cAMP production in cultured rat osteoblasts and stimulate IGF-I expression through a transcriptional mechanism mediated by cAMP dependent protein kinase (PKA)
Hilal et al., J Bone Miner Res 2001 (Osteoarthritis...) : These results suggest that both IGF-1 signaling and PGE2 formation repress PTH dependent response in OA osteoblasts, a situation that can contribute to abnormal bone remodeling and bone sclerosis in OA
Green et al., Kidney Int 2003 (Acidosis...) : PTH also up-regulated its own receptor in control as well as during acidic conditions, and increased the expression levels of IGF-1 and IGF-1 receptor in the acidotic condyle
Kasukawa et al., Endocrinology 2003 (Body Weight...) : Based on these and past findings, we conclude that : 1 ) IGF-I deficiency exaggerates the negative effects of calcium deficiency on bone accretion ; and 2 ) IGF-I deficiency may lead to 1,25-dihydroxyvitamin D deficiency and elevated PTH levels even under normal calcium diet
Schmid et al., Acta Endocrinol (Copenh) 1992 : In contrast to growth hormone, T3 and PTH increased both IGF-1 mRNA expression and net IGF-1 release in calvaria cells
Linkhart et al., Endocrinology 1992 (Bone Resorption) : Indomethacin had a smaller effect on PTH induced IGF-I release and had no significant effect on PTH induced resorption
Zhang et al., Chin Med J (Engl) 2003 : PTH rapidly and constantly stimulates the IGF-I gene transcription of osteoblast
Erclik et al., J Mol Endocrinol 2005 (Osteosarcoma) : Activation of the insulin-like growth factor binding protein-5 promoter by parathyroid hormone in osteosarcoma cells requires activation of an activated protein-2 element
McCarthy et al., Endocrinology 1991 : Although PTH increase cAMP, intracellular calcium, and PGE2 production by bone cells, our previous studies indicate that the stimulatory effect of PTH on IGF-I production is cAMP, but not calcium dependent ... Inhibition of PGE2 synthesis by exposure to indomethacin did not alter basal or PTH stimulated IGF-I levels, substantiating that the effect of PTH on IGF-I is not PGE2 dependent
Wang et al., J Endocrinol 2006 : However, PTH increased the mRNA levels of IGF-I and IGF-IR only in the bones of male mice ... However, PTH increased the mRNA levels of IGF-I and IGF-IR only in the bones of male mice
Wong et al., J Bone Miner Res 1991 : These data suggest that ( 1 ) subclasses of osteoblasts can be further separated by density and ( 2 ) PTH effects on alkaline phosphatase activity and IGF-I secretion are probably expressed by osteoblasts of a certain subclass and/or stage of development
McCarthy et al., Endocrinology 1990 : In Ob cultures, PTH at 10 nM increased IGF-I transcripts at 6 h and polypeptide levels at 24 h by 2.5- and 4.1-fold, respectively, and cortisol opposed this effect
McCarthy et al., J Biol Chem 1990 : Earlier studies indicate that parathyroid hormone (PTH) enhances insulin-like growth factor I (IGF-I) synthesis in primary osteoblast enriched fetal rat cell cultures and the stimulatory effect of PTH on bone collagen synthesis is mediated at least in part by IGF-I
Tørring et al., Endocrinology 1991 : Taken with the known effects of PTH on IGF production in bone cells, the data suggest that PTH and PTHrP may modulate local IGF action in bone through the regulation of specific IGFBP availability
Jilka et al., Bone 2007 : Observations from genetically modified mice suggest that the anabolic effect of intermittent PTH requires insulin-like growth factor-I (IGF-I) , fibroblast growth factor-2 (FGF-2), and perhaps Wnts. Attenuation of the negative effects of PPAR gamma may also lead to increased osteoblast number
Linkhart et al., Endocrinology 1991 (Bone Resorption) : In a previous study we found that PTH stimulated bone resorption and release of insulin-like growth factor-I (IGF-I) and IGF-II from cultured neonatal mouse calvaria ... The results of this and the previous study suggest that PTH , TGF beta, and 1,25- ( OH ) 2D3 differentially regulate mouse calvarial cell IGF-I and IGF-II production
Elis et al., J Bone Miner Res 2010 : There is growing evidence that insulin-like growth factor 1 (IGF-1) and parathyroid hormone (PTH) have synergistic actions on bone and that part of the anabolic effects of PTH is mediated by local production of IGF-1
Lombardi et al., J Endocrinol Invest 2010 (Osteoporosis) : IGF-I and PTH have synergistic actions on bone and some effects of the anabolic actions of PTH are mediated by local production of IGF-I , as has been shown in vitro and in vivo studies both in animals and humans ... PTH can induce skeletal IGF-I expression both in vitro and in vivo ... PTH stimulates the synthesis of IGF-I via a cAMP dependent mechanism, and this factor has pro differentiating and prosurvival effects on osteoblasts
Elford et al., Endocrinology 1990 : Both TGF beta-1 and PTH stimulated IGF-I release from osteoblasts, which was further enhanced when both were consecutively present
McCarthy et al., Endocrinology 1989 : In contrast, PTH- ( 1-34 ) had a biphasic stimulatory effect on IGF-I transcript levels ; 0.1-10 nM PTH increased IGF-I transcripts by 100-200 % after a 6-h treatment, while 100 nM PTH induced a 100 % increase ... In addition, PTH at 0.01-10 nM increased immunoreactive IGF-I ( iIGF-I ) in culture medium by 40-200 % at 24 h. Maximal increases in IGF-I transcripts occurred at 6 h, while iIGF-I accumulated throughout 24 h of culture ... Therefore, PTH enhanced local IGF-I synthesis by increasing IGF-I transcripts, and this effect may in part mediate the anabolic actions of PTH on bone
Linkhart et al., Endocrinology 1989 : Calcitonin inhibited PTH stimulated resorption, but had no effect on PTH stimulation of IGF-I and IGF-II release, suggesting that PTH effects on IGF-I and IGF-II release were not dependent on resorption
Canalis et al., J Clin Invest 1989 : Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures
Pfeilschifter et al., J Clin Invest 1995 : PTH had no effect on circulating IGF-I, suggesting that the increase of bone matrix IGF-I was due to the local effect of PTH on bone tissue directly rather than to an increase of circulating IGF-I
Gunness et al., Bone 1995 : PTH increases bone mass by stimulating bone formation in vivo, and IGF-I partially mediates the stimulatory effect of PTH on collagen synthesis in vitro
Moriwake et al., J Bone Miner Res 1995 (Hypophosphatemia, Familial) : The present results indicate that the low serum IGFBP-3 activity in Hyp mice is not related to hypophosphatemia per se. Based on the documented effects of parathyroid hormone (PTH) on IGF-I and IGFBP-3, we propose that the secondary hyperparathyroidism displayed by Hyp mice and its exacerbation by phosphate supplementation may contribute to low IGFBP-3 levels in control Hyp mice and to the decreases in serum IGF-I and IGFBP-3 in phosphate supplemented Hyp mice
Fujisawa et al., J Pediatr Endocrinol 1996 (Hyperparathyroidism...) : It is hypothesized that the elevation of serum PTH level was induced either by the rise in phosphorus levels induced by GH or by a direct stimulatory effect of IGF-I on PTH production
Nasu et al., FEBS Lett 1997 : Stimulatory effects of parathyroid hormone and 1,25-dihydroxyvitamin D3 on insulin-like growth factor binding protein-5 mRNA expression in osteoblastic UMR-106 cells : the difference between transient and continuous treatments
Kaji et al., J Cell Physiol 1997 (Second Messenger Systems) : Moreover, anti-IGF-I antibody significantly blocked osteoclastlike cell formation stimulated by the conditioned medium from MC3T3-E1 cells pretreated with 10 ( -8 ) PTH- ( 1-34 ), which induced IGF-I and IGFBP-5 mRNA expression in these cells
McCarthy et al., J Biol Chem 1997 : In osteoblasts, IGF-I synthesis is enhanced by parathyroid hormone and prostaglandin E2 ( PGE2 ) through cAMP activated protein kinase
Rihani-Bisharat et al., Endocrinology 1998 : It also revealed that PTH ( 28-48 ) has strong anabolic effects on this model, and suggests that IGF-I might mediate the anabolic effects of PTH ( 28-48 )
Kawane et al., Endocrinology 1999 : IGF-I inhibition of PTH/PTHrP receptor mRNA expression in UMR-106 cells was abrogated completely by pretreatment with cycloheximide, an inhibitor of protein synthesis