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PTGS2 — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT3 → PTGS2 (increases, PTGS2 Activity, STAT3 Activity)
  Evidence: We show that A549 cells overexpressing COX-2 have constitutive STAT3 (Tyr705 and Ser727) activation, whereas A549 cells with limited COX-2 lacked this activation
• OpenBEL Selventa BEL large corpus: STAT3 → PTGS2 (increases, STAT3 Activity)
  Evidence: We show that A549 cells overexpressing COX-2 have constitutive STAT3 (Tyr705 and Ser727) activation, whereas A549 cells with limited COX-2 lacked this activation

Text-mined interactions from Literome

Xuan et al., Circulation 2005 (MAP Kinase Signaling System) : In mice preconditioned with six 4-minute coronary occlusion/4-minute reperfusion cycles, we found that ( 1 ) ischemic PC activates the Raf1-mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK) 1/2-p44/42 MAPK signaling pathway, induces phosphorylation of STAT1 and STAT3 on the Ser-727 residue, and upregulates COX-2 expression ; ( 2 ) pSer-STAT1 and pSer-STAT3 form complexes with pTyr-p44/42 MAPKs in preconditioned myocardium, supporting the concept that Ser phosphorylation of these 2 factors is mediated by activated p44/42 MAPKs ; and ( 3 ) activation of the Raf-1-MEK-1/2-p44/42 MAPK-pSer-STAT1/3 pathway and induction of COX-2 during ischemic PC are dependent on protein kinase C (PKC)-epsilon activity, as determined by both pharmacological and genetic inhibition of PKCepsilon
Han et al., J Biol Chem 2006 : In parallel, activation of COX-2/PGE ( 2 ) signaling also enhances Stat3 phosphorylation and reporter activity through EP ( 1 ) receptor induced activation of c-Src and EGFR in these cells
Kim et al., J Cereb Blood Flow Metab 2008 : Additionally, inhibition of STAT3 prevented PC-induced COX-2 expression and neuroprotection against OGD ... Finally, we show that STAT3 activation mediates COX-2 expression and ischemic tolerance
Perra et al., FASEB J 2008 (Disease Models, Animal...) : To investigate whether T3 could also reverse fully established fatty liver, rats were fed a CMD diet for 10 wk and then cofed T3 for 1 wk. Coadministration of T3 resulted in a complete regression of liver steatosis associated with a decrease of lipid peroxidation, cyclooxygenase-2 expression, and activation of phospho-STAT3 and phospho-SAPK/JNK
Kim et al., Free Radic Biol Med 2008 : The inhibition of STAT1 and STAT3 by EP prevented their translocation to the nucleus and consequently inhibited expression of iNOS and COX-2 by inhibiting STAT1- and STAT3 mediated transcriptional activity, followed by changes in chromatin conformation via deacetylation of histones H3 and H4 in both gene promoters
Gao et al., Cancer Sci 2009 (Endometrial Neoplasms) : Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3 , MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells
Lo et al., Mol Cancer Res 2010 (Brain Neoplasms...) : Increased expression of EGFR/EGFRvIII and activated STAT3 leads to the synergistic activation of the COX-2 promoter ... Promoter mutational analysis identified a proximal STAT3 binding site that is required for EGFR/EGFRvIII-STAT3 mediated COX-2 gene activation
Min et al., Int Immunopharmacol 2011 (Inflammation) : Taken together, these results suggest that withaferin A inhibits LPS induced PGE ( 2 ) production and COX-2 expression, at least in part, by blocking STAT1 and STAT3 activation