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IGF1 — PTGS2

Text-mined interactions from Literome

Di Popolo et al., Oncogene 2000 (Disease Progression...) : Up-regulation of COX-2 expression by IGF-II is mediated through activation of IGF-I receptor because: (i) treatment of Caco-2 cells with a blocking antibody to the IGF-I receptor inhibits COX-2 mRNA expression ; ( ii ) transfection of Caco-2 cells with a dominant negative IGF-I receptor reduces COX-2 expression and activity
Cao et al., Cell Signal 2007 (MAP Kinase Signaling System...) : Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells ... Herein we showed that IGF-I efficiently induced COX-2 expression and PGE ( 2 ) biosynthesis at physiologically relevant concentrations in human ovarian cancer cells ... We next investigated the signaling pathways involved in IGF-I induced COX-2 expression ... We found that PI3K inhibitor wortmannin or LY294002 blocked COX-2 expression induced by IGF-I ... We showed that ERK1/2 and p38 MAPKs were required for IGF-I induced COX-2 expression and that activation of both pathways by IGF-I increased COX-2 transcriptional activation and its mRNA stability ... IGF-I stimulated PKC activation in the cells and pretreatment with PKC inhibitor bisindolylmaleimide prevented IGF-I induced COX-2 transcriptional activation and mRNA stabilization, and inhibited COX-2 mRNA and protein expression ... Taken together, our data demonstrate that IGF-I induces COX-2 expression in human ovarian cancer cells, which is mediated by three parallel signaling cascades -- PI3K, MAPK, and PKC pathways that differentially regulate COX-2 expression at transcriptional and post-transcriptional levels
Nguyen et al., Am J Pathol 2007 (Stomach Ulcer) : Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing : promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase dependent manner ... We also examined whether IGF-1 induces cyclooxygenase (COX)-2 expression and determined the role of phosphatidylinositol 3-kinase and mitogen activated protein kinase signaling pathways in mediating IGF-1 actions ... Inhibitor of phosphatidylinositol 3-kinase abolished IGF-1 induced RGM1 cell migration and proliferation, actin polymerization, and COX-2 expression
Stoeltzing et al., Cancer Lett 2007 (Pancreatic Neoplasms) : Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor ( IGF-IR ) system ... We hypothesized that IGF-IR is directly involved in induction of COX-2 and sought to investigate signaling pathways mediating this effect ... IGF-I up-regulated COX-2 selectively via the MAPK/ ( Erk-1/2 ) pathway
Tian et al., Mol Carcinog 2012 (Neovascularization, Pathologic) : Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands
Guan et al., Am J Physiol 1998 : We demonstrate that both insulin and IGF-I increase IL-1 beta induced Cox-2 and iNOS protein expression, which in turn enhance PGE2 and NO production