Gene interactions and pathways from curated databases and text-mining

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AKT1 — PTGS2

Text-mined interactions from Literome

Sheng et al., Cancer Res 2001 (MAP Kinase Signaling System) : K-Ras mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1 ... Here we investigate the role of Akt/PKB in K-Ras mediated induction of COX-2 ... Here we investigate the role of Akt/PKB in K-Ras mediated induction of COX-2 ... Inhibition of MAPK/ERK kinase activity by PD 98059 completely blocked the K-Ras mediated induction of COX-2, whereas inhibition of PI3K/Akt/PKB activity with LY 294002 or by expressing a dominant negative Akt ( Akt-K179M ) partially blocked the induction of COX-2 by K-Ras ... Inhibition of MAPK/ERK kinase activity by PD 98059 completely blocked the K-Ras mediated induction of COX-2, whereas inhibition of PI3K/Akt/PKB activity with LY 294002 or by expressing a dominant negative Akt ( Akt-K179M ) partially blocked the induction of COX-2 by K-Ras ... Thus, Akt/PKB activity is involved in K-Ras induced expression of COX-2 and stabilization of COX-2 mRNA largely depends on the activation of Akt/PKB
Tang et al., Cancer Res 2001 : Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes ... We examined whether Akt and glycogen synthase kinase 3beta ( GSK-3beta ), components of the phosphatidylinositol 3'-kinase pathway, are involved in UVB induction of COX-2 transcription
Lee et al., J Biol Chem 2003 : AKT ( CA ) was sufficient to induce NFkappaB activation and COX-2 expression
Simeone et al., Cancer Res 2004 (Breast Neoplasms) : We show that HER2/neu uses Akt to induce cyclooxygenase-2 (COX-2) expression and that inhibition of Akt or COX-2 increases 4-HPR induced apoptosis and nitric oxide production
St-Germain et al., Molecular cancer 2004 (Endometrial Neoplasms) : Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway ... Recently, we showed that Akt regulates COX-2 gene and protein expressions in phospho-Akt expressing endometrial cancer cells
St-Germain et al., Int J Oncol 2004 (Endometrial Neoplasms) : Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells ... On the opposite, activation of Akt using a constitutively active expression vector, resulted in the up-regulation of COX-2 protein expression
Baoping et al., Dig Dis Sci 2004 (Stomach Neoplasms) : We aimed to study the effects of the selective COX-2 inhibitor, nimesulide, on cell viability and telomerase and Akt/PKB activity in the human gastric cancer cell line MKN-45 and to explore the molecular mechanism for the antitumor activity of the selective COX-2 inhibitor
Chang et al., Mol Pharmacol 2004 : YC-1 induced cyclooxygenase-2 expression is mediated by cGMP dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt , and nuclear factor-kappaB in human pulmonary epithelial cells ... In this study, we explore the role of Ras, phosphoinositide-3-OH-kinase (PI3K), Akt , and transcription factor nuclear factor-kappaB (NF-kappaB) in YC-1 induced COX-2 expression in A549 cells ... A Ras inhibitor ( manumycin A ), a PI3K inhibitor ( wortmannin ), an Akt inhibitor ( 1l-6-Hydroxymethyl-chiro-inositol2- [ ( R ) -2-O-methyl-3-O-octadecylcarbonate ] ), and an NF-kappaB inhibitor [ pyrrolidine dithiocarbamate ( PDTC ) ] all reduced YC-1 induced COX-2 expression ... Taken together, these results indicate that YC-1 might activate the sGC/cGMP/PKG pathway to induce Ras and PI3K/Akt activation, which in turn initiates IKKalpha/beta and NF-kappaB activation and finally induces COX-2 expression in A549 cells
Davies et al., Carcinogenesis 2006 (Choline Deficiency...) : These results suggest that the SC-236 induced reduction of M2PK positive oval cell numbers may be due to COX-2 dependent inhibition of Akt phosphorylation and induction of apoptosis
Schmitz et al., J Clin Pathol 2006 (Breast Neoplasms) : The prognostic effect of COX-2 expression on lymph node negative breast cancer is confirmed-COX-2 is probably not regulated by HER-2, Akt , Erk1/2 or p38
Colleselli et al., Exp Cell Res 2006 : COX-2 inhibition leads further to an increased cleavage of caspase-3 protein and inversely to inhibition of Akt activation
Pan et al., Biochem Pharmacol 2006 (Cocarcinogenesis...) : Taken together, these results show that acacetin down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Hwang et al., Carcinogenesis 2007 : Co-treatment of mouse skin with the IKKbeta-specific inhibitor SC-514 ( 1 micromol ) attenuated TPA induced activation of Akt and NF-kappaB, and also the expression of COX-2 in hairless mouse skin ... Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects
Tseng et al., Oral Oncol 2007 (Carcinoma, Squamous Cell...) : Activation of AKT by 1.7-fold and up-regulation of COX-2 by 2-fold were elicited following ANE treatment in NHOK
Liu et al., Mol Immunol 2007 : Further studies show that the triptolide mediated inhibitory effects of LPS induced activation of phosphatidylinositol-3 kinase (PI3-K)/Akt and nuclear NF-kappaB activation are involved in down-regulation of COX-2 and CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
Chung et al., Carcinogenesis 2007 (Acute Disease...) : Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC, iNOS and COX-2 regulated by the NF-kappaB, mitogen activated protein kinases and/or Akt
Kim et al., J Med Food 2007 : Taken together, these experiments demonstrated that IOE70 inhibition of LPS induced expression of iNOS and COX-2 protein is mediated by Akt and JNK
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids potently stimulated COX-2 expression and induced AKT and ERK1/2 phosphorylation in concert with COX-2 induction ... Dominant negative ( DN ) AKT and LY294002 ( PI3K inhibitor ) or U0126 ( MEK-1/2 inhibitor ) blocked chenodeoxycholic acid ( CD ) and deoxycholic acid ( DC ) mediated COX-2 induction ... Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Hsu et al., Cell Signal 2007 : Ultrasound induces cyclooxygenase-2 expression through integrin, integrin linked kinase, Akt , NF-kappaB and p300 pathway in human chondrocytes
Ploplis et al., J Pathol 2007 (Adenomatous Polyposis Coli...) : These latter effects are consistent with a mechanism involving up-regulation of COX-2 expression and Akt pathway activation in Apc ( Min/+ ) /Plau-/- mice
Kim et al., Carcinogenesis 2008 (Breast Neoplasms) : 15d-PGJ ( 2 ) -induced COX-2 expression was mediated by activation of Akt and subsequently activator protein-1 (AP-1)
Chang et al., J Ethnopharmacol 2008 (Carcinoma, Hepatocellular...) : Furthermore, solid-state extracts of Antrodia camphorata ( AC-SS ) showed its adjuvant effects through the inhibition of MDR gene expressions and the pathway of COX-2- dependent inhibition of p-AKT , which ultimately resulted in the induction of apoptosis in hepatoma cells
Pan et al., J Agric Food Chem 2008 : Taken together, these results show that pterostilbene down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK
Chen et al., Mol Immunol 2009 : PGN induced COX-2 expression was attenuated by a Rac1 dominant negative mutant ( RacN17 ), PI3K inhibitors ( wortmannin and LY 294002 ), and an Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol2- [ ( R ) -2-O-methyl-3-O-octadecylcarbonate ] )
Gao et al., Cancer Sci 2009 (Endometrial Neoplasms) : Leptin induced functional activation of COX-2 is JAK2/STAT3-, MAPK/ERK-, and PI3K/AKT dependent , indicating that COX-2 may be a critical factor of endometrial carcinogenesis in obesity
Roy et al., Invest New Drugs 2010 (Lung Neoplasms) : Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice
Liao et al., Toxicol Lett 2009 : Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS dependent cyclooxygenase-2 expression in endothelial cells
Uddin et al., Int J Cancer 2010 (Ovarian Neoplasms) : Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer
Moore et al., Carcinogenesis 2009 (Adenoma...) : Pharmacological inhibition of MEK and PI3K suggested that both extracellular signal regulated kinase ( ERK ) and AKT signalling are required for COX-2 protein up-regulation and 15-PGDH down-regulation downstream of Met
Kim et al., Mol Cancer Res 2009 : COX-2 induced activation of extracellular signal regulated kinase ( ERK ) and c-Jun NH ( 2 ) -terminal kinase ( JNK ) but suppressed Akt activation
Anggakusuma et al., J Dermatol Sci 2010 (Inflammation) : These results suggest that macelignan protects skin keratinocytes from UVB induced damage and inhibits MMP-9 and COX-2 expression by attenuating the activation of MAPKs and PI3K/Akt
Chen et al., Mol Pharmacol 2010 (Lung Neoplasms) : Inhibiting Akt markedly suppressed COX-2 expression, suggesting COX-2 is a downstream effector of this cell survival kinase mediated apoptosis resistance
Shrotriya et al., Cancer Res 2010 (Skin Neoplasms) : Diallyl trisulfide inhibits phorbol ester induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling ... Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA treated mouse skin
Lu et al., J Cell Biochem 2010 (Glioma) : One mechanism underlying bradykinin directed migration is transcriptional up-regulation of COX-2 and activation of the B1R receptor, PI-3 kinase, AKT , c-Jun, and AP-1 pathways
Lin et al., Int Immunopharmacol 2010 : On the other hand, PGN induced iNOS and COX-2 up-regulation were attenuated by PI3-kinase inhibitors ( LY294002 and wortmannin ), and an AKT inhibitor
Lin et al., Int Immunopharmacol 2010 : CORM-2 time-dependently induced the phosphorylation of Akt and MAPKs, and the induction of COX-2 could be blocked by Akt , PKG, and MAPKs inhibitors
Kim et al., Pharmacology 2010 (Breast Neoplasms) : COX-2 expression was increased by CA-MEK transfection, but not by myr-Akt
Singh et al., Biol Reprod 2011 : Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT dependent manner
Garonna et al., PloS one 2011 : Inhibition of VEGFR2 tyrosine kinase activity reduced leptin stimulated p38 ( MAPK ) and Akt activation, COX-2 induction , and pro-angiogenic EC responses, and blockade of VEGFR2 or COX-2 activities abolished leptin-driven neo-angiogenesis in a chick chorioallantoic membrane vascularisation assay in vivo
Han et al., J Biol Chem 2011 : Inhibiting AKT by caffeine blocked UVB induced COX-2 up-regulation
de Oliveira et al., Journal of neuroinflammation 2012 : Taken together, we demonstrate that blockade of mTOR and/or PI3K/Akt enhances prostanoid production and that PI3K/Akt , GSK-3 and mTOR differently regulate the expression of mPGES-1 and COX-2 in activated primary microglia
Cho et al., Cell Physiol Biochem 2012 (MAP Kinase Signaling System) : Among the signaling components of FceRI, Fyn, PI 3-kinase, Akt , and p38 MAPK positively mediated the COX-2 expression
Hill et al., Mol Cancer Ther 2012 (Carcinoma, Pancreatic Ductal...) : Mechanistically, COX-2 overexpression increases p-AKT levels in the precursor lesions of Pdx1 ( + ) ; K-ras ( G12D ) ( /+ ) ; Pten ( lox ) ( /+ ) mice in the absence of Pten LOH
Sabarinathan et al., Mol Cell Biochem 2013 (Brain Neoplasms...) : In conclusion, it can be argued that the reduced expressions of phosphatidylinositol 3-kinase and protein kinase B in naringenin treated glioma induced rat brain might be involved in the down-regulation of cyclooxygenase-2 expression and activity
Bertrand et al., Apoptosis 2013 : Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents ... Our findings highlighted that COX-2 can positively regulate Akt signalling mostly through PTEN inhibition, partly via casein kinase 2 activation, and enhances survival of erythroleukemia cells exposed to anticancer agents