◀ Back to IGF1
IGF1 — PTEN
Text-mined interactions from Literome
Tanno et al., Cancer Res 2001
(Neoplasm Invasiveness...) :
Furthermore, AKT induced
IGF-IR expression was
down-regulated by dominant negative Src or
PTEN
Zhang et al., Chin J Cancer 2002
(Endometrial Neoplasms) :
[
Role of suppressor encoprotein
PTEN in
IGF-1 induced activation of ERK in endometrial carcinoma cells ]
Zhao et al., Oncogene 2004
(Prostatic Neoplasms) :
Interestingly,
PTEN overexpression
resulted in a 44-60 % reduction in total insulin-like growth factor-I receptor (
IGF-IR ) protein levels and a 49-64 % reduction in cell surface IGF-IR expression ... [ 35S ] methionine pulse experiments in PC3 cells overexpressing PTEN demonstrated that these cells synthesize significantly lower levels of the IGF-IR precursor, whereas
PTEN overexpression
had no effect on
IGF-IR degradation
Yi et al., Biochem Biophys Res Commun 2005
(Adenocarcinoma...) :
PTEN overexpression
resulted in a significant decrease in the expression of
IGF-I , -II, and IGF-IR ...
PTEN overexpression
resulted in a significant decrease in the expression of IGF-I, -II, and
IGF-IR
Al-Khouri et al., J Biol Chem 2005
:
Finally,
PTEN phosphorylation was
affected by
insulin-like growth factor in intact cells
Hwang et al., Exp Mol Med 2005
(Stomach Neoplasms) :
PTEN overexpression
induced a profound decrease in the IGF-II and
IGF-IR expression levels, and downregulation of IGF-II expression by PTEN was mediated through the regulation of the IGF-II promoter
Ma et al., J Surg Res 2010
(Carcinoma...) :
IGF-1 mediates
PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells
Jones et al., Lancet Oncol 2009
(Breast Neoplasms) :
Potential mechanisms of resistance to trastuzumab include bypass mechanisms, mutations of the HER2 target, masking of HER2 proteins,
inhibition of
insulin-like growth factor , and
phosphatase and tensin homologue (PTEN) deficiency
Wu et al., Oncol Rep 2013
:
We found that
IGF-1 enhanced CM cell proliferation and
inhibited both
PTEN and PHLPP2 activity in a concentration- and time dependent manner