Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — PTCH1

Text-mined interactions from Literome

Yamashita et al., Translational oncology 2013 : This study revealed that RET/PTC and BRAF ( T1799A ) activate Notch signaling and promote tumor growth in thyroid follicular cell
Redmond et al., Arterioscler Thromb Vasc Biol 2013 (Carotid Artery Injuries...) : Inhibition of Ptc-1 by cyclopamine attenuated low flow induced increases in Notch expression while concomitantly decreasing human coronary arterial smooth muscle cell growth to that similar under normal flow conditions ... These results suggest that pathological low flow stimulates smooth muscle cell growth in vitro and vascular remodeling in vivo via Ptc-1 regulation of Notch signaling