Gene interactions and pathways from curated databases and text-mining

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IGF1 — PRL

Text-mined interactions from Literome

Yoshizato et al., Endocr J 2000 : IGF-I gene expression was increased by 20K and 22K hGH stimulation, but not by PRL or IL-3 in the Ba/F3-hGHR
Fruchtman et al., Endocrinology 2000 : Insulin-like growth factor I disparately regulates prolactin and growth hormone synthesis and secretion : studies using the teleost pituitary model ... Taken together, these findings clearly indicate that IGF-I disparately regulates PRL and GH synthesis and secretion
Tonner et al., Adv Exp Med Biol 2000 : IGF-I is an important survival factor for the mammary gland and we have demonstrated that the effects of GH and prolactin involve IGF-I
Yang et al., J Anim Sci 2000 : We hypothesized that Stat5 may serve as a common point in the signal transduction pathways of hormones that promote milk protein gene expression in bovine mammary cells, which are regulated by GH and IGF-I in addition to prolactin
Fruchtman et al., Comp Biochem Physiol B Biochem Mol Biol 2001 : Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways
Kajimura et al., Gen Comp Endocrinol 2002 : By contrast, PRL ( 188 ) release was stimulated significantly and in a dose related manner by IGF-I at concentrations higher than 10 ng/ml and by IGF-II at concentrations higher than 100 ng/ml within 2h
Fernández et al., Neuroendocrinology 2003 : In previous studies we demonstrated that insulin-like growth factor I (IGF-I) induces pituitary vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I induced prolactin (PRL) release is mediated by VIP
Reiter et al., Mol Cell Endocrinol 1992 : Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats
Peri et al., Cell Biol Int Rep 1992 : Neither Des-3-IGF-I nor IGF-II exhibited galactopoietic activity nor did they affect the galactopoietic activity of prolactin
Mukherjee et al., J Clin Endocrinol Metab 2006 (Hypopituitarism...) : Effects of hypoprolactinemia are not well described in humans, but laboratory studies suggest a role for prolactin in hepatic IGF-I release, possibly through a signal transducer and activator of transcription 5 ( STAT5 ) pathway
Billestrup et al., Endocrinology 1991 : The stimulatory effect of growth hormone, prolactin , and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I ... These data suggest that the stimulatory effect of GH, PRL , and PL on beta-cell proliferation is not mediated by IGF-I , but, rather, is a direct mitogenic effect on the beta-cell
Romano et al., Endocrinology 2006 : The IGF-I stimulated PRL secretion was diminished, on the contrary, by the pharmacological PI3K/Akt inhibitors
Carver et al., Mol Cancer Res 2008 (Breast Neoplasms...) : Here, we investigate the relationship between these factors and show that prolactin up-regulated transcript levels of both IGF-I and IGF-II, but only after increases in cyclin D1 protein were observed
Matsumoto et al., Mol Hum Reprod 2008 : MPA and E ( 2 ) induced decidualization of stromal cells, while LR ( 3 ) -IGF-I inhibited decidualization by MPA and E ( 2 ) as well as PRL and IGFBP-1 secretion into medium
Gala et al., Proc Soc Exp Biol Med 1991 (Dwarfism, Pituitary...) : The effect of PRL on insulin-like growth factor I production by these cells has not been examined
Hikake et al., Experimental biology and medicine (Maywood, N.J.) 2010 : Estrogen and insulin-like growth factor-I (IGF-I) stimulate prolactin (PRL) production, release and proliferation of PRL producing cells (PRL cells) in the anterior pituitary
Handwerger et al., Ann N Y Acad Sci 1991 : In addition, the synthesis and release of decidual prolactin are stimulated by IGF-I , insulin and relaxin, each acting through distinct plasma membrane receptors ... The demonstration that the synthesis and release of decidual prolactin are regulated by PRL-RF, IGF-I , insulin, relaxin, arachidonic acid, PRL-IF and lipocortin I strongly suggests that there is novel autocrine/paracrine feedback regulation between the placenta, fetal membranes, and decidua in the regulation of decidual prolactin
Binnerts et al., Eur J Cancer 1990 (Body Weight...) : The direct effects of human GH and IGF-I on PRL secretion and cell proliferation were studied on PRL secreting rat pituitary tumor 7315b cells in vitro, as well as the effects in vivo of human GH administration on body weight, IGF-I levels and tumor size in rats bearing this transplantable tumor ... In the in vitro studies IGF-I levels above 5 nM stimulated PRL release in a dose dependent manner while GH, in concentrations of 0.23-45 nM, did not affect PRL release
Bernabeu et al., Pituitary 2013 (Acromegaly) : Baseline IGF-I levels, female gender, body weight, and PRL levels affect the response to this combination therapy
Shushanov et al., Bull Exp Biol Med 2011 : It was found that both IGF-1 and IGF-2 activate the expression of milk protein ß-casein in the presence of prolactin and hydrocortisone
Murphy et al., Endocrinology 1988 (Body Weight) : Stimulation of hepatic insulin-like growth factor-I gene expression by ovine prolactin : evidence for intrinsic somatogenic activity in the rat ... The effect of ovine PRL ( oPRL ) on hepatic insulin-like growth factor I (IGF-I) gene expression was examined in the hypophysectomized ( hypox ) rat and compared with that seen in hypox rats treated with ovine GH ( oGH ) and human GH ( hGH )
Thrailkill et al., Endocrinology 1989 : We have reported that IGF-I stimulates the release of decidual PRL , acting through the type I IGF receptor ( 1 )
Thrailkill et al., Endocrinology 1988 : Insulin-like growth factor I stimulates the synthesis and release of prolactin from human decidual cells ... To examine whether IGF-I may also regulate the release of PRL from human decidual tissue, we have investigated the effect of recombinant human IGF-I on PRL release from monolayer cultures of human decidual cells exposed to IGF-I for up to 4 days ... IGF-I ( 10-1000 ng/ml ) stimulated a sustained dose dependent increase in PRL release ( half-maximal concentration, 25 ng/ml ) beginning 48 h after initial exposure, but had no effect on the intracellular PRL content ... Furthermore, exposure of decidual cells to a monoclonal antibody to the IGF-I receptor ( alpha-IR3 ) completely inhibited both IGF-I mediated PRL release and specific binding of [ 125I ] IGF-I to decidual cells ... Since the actions of IGF-I occurred at physiological concentrations, these findings strongly support a role for IGF-I in the regulation of PRL secretion by human decidua
Snyder et al., Exp Lung Res 1987 : While insulin, bovine prolactin , and human growth hormone had no apparent effect on Sm-C/IGFI production by the explants, human prolactin and human placental lactogen both decreased Sm-C/IGFI production
Yamashita et al., J Clin Invest 1987 : IGF-I ( 3.25 nM ) also inhibited the twofold growth hormone releasing hormone (GHRH) ( 10 nM ) -stimulated GH gene transcription by 30 % after 4 h. Transcription of the prolactin (PRL) gene was not suppressed in these cells by IGF-I
Irwin et al., Regul Pept 1993 : The decrease in IGFBP-1 levels in decidualized stromal cultures was associated with the induction of mitogenesis by IGF-I and IGF-II, while IGF effects on prolactin secretion paralleled those of IGFBP-1 secretion, with stimulation ( 243-324 % ) in the low concentration range followed by inhibition at higher concentrations
Atkin et al., Clin Endocrinol (Oxf) 1994 (Adenoma...) : The effects of 100 nM IGF-I on GH, PRL and alpha-subunit secretion were determined over 4-hour and over 4-day periods, and a 4-day dose-response study using 1-100 nM IGF-I was performed on two tumours ... IGF-I also increased PRL secretion in 2/2 prolactinomas ( 27 and 32 %, P < 0.05 ) compared with control ... GH was inhibited and PRL secretion was stimulated by 1 and 10 nM IGF-I in the two dose-response studies ... IGF-I inhibited tumorous GH in 62 % and stimulated PRL secretion in 71 % of tumours over 4 days, without affecting alpha-subunit secretion or being mitogenic for somatotrophinoma cells in vitro
Arosio et al., J Endocrinol Invest 1995 (Anencephaly...) : Altogether these data support the views that a ) both GH and PRL secretion are under the hypothalamic control during fetal development, b ) the serum GH decrease from midgestation to the end of pregnancy is mediated by the negative feed-back mechanism of increasing IGF-I levels and c ) IGF-I production is mainly regulated by fuel supply and only partially by GH
Nakago et al., Nihon Naibunpi Gakkai Zasshi 1995 : To elucidate the effects of growth hormone (GH), prolactin (PRL) , and human placental lactogen (hPL) on the regulation of insulin-like growth factor ( IGF-1 ), we compared plasma IGF-1 levels, the pattern of circulating IGF-1-IGF binding protein complexes ( IGF-1 complexes ), and unsaturated binding protein ( USBP ) levels among 1 ) naturally growing Wistar rats at several developmental stages, 2 ) rats subcutaneously administered GH, and 3 ) hypophysectomized rats treated with each of the three hormones
Lara et al., Endocrinology 1994 : The effects of recombinant human insulin-like growth factor I (IGF-I) on both vasoactive intestinal peptide (VIP) and PRL production and gene expression were studied using rat anterior pituitary cell cultures grown in serum-free defined medium ... Immunoglobulins G purified from VIP antiserum inhibited IGF-I induced PRL release without affecting intracellular and mRNA levels ... In conclusion, these results indicate that IGF-I induces VIP gene expression, and its secretion and also increases PRL secretion ... The effect of IGF-I on PRL release is specifically mediated by VIP through a paracrine or autocrine mechanism
Nowak et al., J Clin Endocrinol Metab 1993 (Leiomyoma...) : 17 beta-Estradiol, progesterone, TRH, insulin-like growth factor-I , epidermal growth factor, and the GnRH agonist leuprolide did not affect PRL secretion by these SMC
Castillo et al., Endocrinology 1997 : Thus, a different effect of IGF-1 on the expression of GHF-1/Pit-1 in GH3 and GH4C1 cells is likely involved in the different regulation of GH and PRL gene in both cell types ... IGF-1 increases the activity of the PRL promoter in transient transfection assays in GH4C1 cells by a Ras dependent mechanism ... Although IGF-1 did not stimulate the PRL promoter in GH3 cells, Ras ( Val12 ) strongly activated the promoter in these cells
Chowen et al., J Neuroendocrinol 1998 : IGF-I inhibited the E induced rise in PRL and lactotroph Pit-1 mRNA levels only in females