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AKT1 — PRKDC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: AKT1 — PRKDC (affinity chromatography technology) Dragoi et al., EMBO J 2005*
• IRef Bind_translation Interaction: AKT1 — PRKDC (coimmunoprecipitation) Dragoi et al., EMBO J 2005*
• IRef Biogrid Interaction: AKT1 — PRKDC (direct interaction, pull down) Dragoi et al., EMBO J 2005*
• IRef Biogrid Interaction: AKT1 — PRKDC (physical association, affinity chromatography technology) Feng et al., J Biol Chem 2004*
• IRef Biogrid Interaction: AKT1 — PRKDC (direct interaction, enzymatic study) Feng et al., J Biol Chem 2004*
• IRef Biogrid Interaction: AKT1 — PRKDC (physical association, affinity chromatography technology) Dragoi et al., EMBO J 2005*
• IRef Hprd Interaction: AKT1 — PRKDC (in vitro) Feng et al., J Biol Chem 2004*

Text-mined interactions from Literome

Dragoi et al., EMBO J 2005 : DNA-PKcs , but not TLR9, is required for activation of Akt by CpG-DNA ... Further in vitro analysis using purified DNA-PK and recombinant Akt proteins reveals that DNA-PK directly induces phosphorylation and activation of Akt
Bozulic et al., Mol Cell 2008 : PKB activation following DNA damage requires 3-phosphoinositide dependent kinase 1 ( PDK1 ) and DNA dependent protein kinase (DNA-PK)
Boehme et al., Proc Natl Acad Sci U S A 2008 : Correspondingly, down-regulation of DNA-PK prevented phosphorylation of Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53 ... Correspondingly, down-regulation of DNA-PK prevented phosphorylation of Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53
Surucu et al., J Biol Chem 2008 : However, the physiological role of DNA-PK in the regulation of PKB phosphorylation remains to be established
Bozulic et al., Curr Opin Cell Biol 2009 (Neoplasms) : This present review concerns PKB regulation by mTORC2 and DNA-PK in a stimulus dependent and context dependent manner and the possible implications of this for PKB activity, substrate specificity and therapeutic intervention
Mukherjee et al., Cancer Res 2009 (Brain Neoplasms...) : These in vitro and in vivo data support our hypothesis that EGFRvIII expression promotes DNA-PKcs activation and DSB repair, perhaps as a consequence of hyperactivated PI3K/Akt-1 signaling
Kim et al., Biochem Pharmacol 2009 : We revealed that siRNA mediated suppression of DNA-PKcs led to decreased phosphorylation of Akt and Bad, a target molecule of Akt, and increased expression of DR4/DR5
Mannell et al., Cell Signal 2010 : The DNA dependent protein kinase (DNA-PK) , long known for its importance in repairing DNA double strand breaks, belongs to the phosphatidylinositol-3 kinase (PI3-K) super family and has recently been identified as one of the enzymes phosphorylating and activating Akt
Rajagopalan et al., Science signaling 2010 (Inflammation) : CD158d associated with the catalytic subunit of DNA dependent protein kinase ( DNA-PKcs ), promoted the recruitment of Akt to endosomes, and stimulated the DNA-PKcs dependent phosphorylation of Akt
Urano-Tashiro et al., J Neurosci Res 2010 : Implication of Akt dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation ... Here, we demonstrated that PRP19 alpha/14-3-3beta/CDC5L complex formation is regulated by Akt during nerve growth factor (NGF) induced neuronal differentiation of PC12 cells
Zhang et al., Blood 2011 : Moreover, increased AKT ( Ser473 ) phosphorylation was observed in activated B cells, reminiscent of cancers treated with rapamycin, and was reduced by a DNA-pk inhibitor
Minjgee et al., Int J Radiat Oncol Biol Phys 2011 : K-RAS ( V12 ) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR dependent Akt signaling and activation of DNA-PKcs
Stronach et al., Neoplasia (New York, N.Y.) 2011 (Carcinoma...) : DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance ... Insulin mediated activation of AKT is unaffected by DNA-PK inhibitor treatment, suggesting that this effect is restricted to DNA damage mediated activation of AKT and that, clinically, DNA-PK inhibition might prevent platinum induced AKT activation without interfering with normal glucose homeostasis, an unwanted toxicity of direct AKT inhibitors
Furusawa et al., Cancer Lett 2012 (Leukemia) : Inhibition of ataxia-telangiectasia mutated (ATM) or DNA-PK revealed that DNA-PK , rather than ATM, was preferentially involved in Akt phosphorylation and cell survival after US-exposure in all cell lines
Toulany et al., Mol Cancer Res 2012 : Akt1 dependent DNA-PKcs kinase activity stimulates autophosphorylation of DNA-PKcs at S2056 that is needed for efficient DNA-DSB repair and the release of DNA-PKcs from the damage site ... The data showed indicate for the first time that Akt through an immediate complex formation with DNA-PKcs can stimulate the accumulation of DNA-PKcs at DNA-DSBs and promote DNA-PKcs activity for efficient NHEJ DNA-DSB repair
Li et al., J Biol Chem 2013 : Chemical inhibition of DNA-PK , knockdown or deficiency of DNA-PK catalytic subunit (DNA-PKcs), or knock-out of the DNA-PK component Ku86 inhibited rapamycin induced Akt phosphorylation ... Accordingly, simultaneous inhibition of mTOR and DNA-PK did not stimulate Akt activity and synergistically inhibited the growth of cancer cells both in vitro and in vivo