Gene interactions and pathways from curated databases and text-mining

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IGF1 — PRKCZ

Text-mined interactions from Literome

Haq et al., Nat Med 2003 (Cardiomegaly) : Absence of cytosolic PLA2 leads to sustained activation of the IGF-1 pathway, which results from the failure of 3-phosphoinositide dependent protein kinase ( PDK)-1 to recruit and phosphorylate protein kinase C (PKC)-zeta , a negative regulator of IGF-1 signaling
Valverde et al., Endocrinology 1996 : Involvement of Raf-1 kinase and protein kinase C zeta in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades : inhibition by cyclic adenosine 3',5'-monophosphate ... Downstream from Ras, IGF-I increased both Raf kinase and protein kinase C (PKC) zeta activities by 3.5-fold