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MLST8 — PRKCA

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) → PKC alpha (PRKCA) (regulation of protein stability, activates) Ikenoue et al., EMBO J 2008
  Evidence: mutant phenotype
• NCI Pathway Database mTOR signaling pathway: mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) → PKC alpha (PRKCA) (modification, activates) Sarbassov et al., Curr Biol 2004, Guertin et al., Dev Cell 2006, Ikenoue et al., EMBO J 2008
  Evidence: mutant phenotype
• WikiPathways Target Of Rapamycin (TOR) Signaling: Complex of MLST8-MTOR-MAPKAP1-RICTOR → PRKCA (activation)

Text-mined interactions from Literome

Guertin et al., Dev Cell 2006 : mLST8 is necessary to maintain the rictor-mTOR, but not the raptor-mTOR, interaction, and both mLST8 and rictor are required for the hydrophobic motif phosphorylation of Akt/PKB and PKCalpha , but not S6K1
Dibble et al., Mol Cell Biol 2009 : However, Rictor-T1135 phosphorylation does not appear to regulate mTORC2 mediated effects on SGK1 or PKC alpha