Gene interactions and pathways from curated databases and text-mining

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NOS1 — PRKAG1

Text-mined interactions from Literome

Fleming et al., Thromb Haemost 2003 : AMP activated protein kinase (AMPK) regulates the insulin induced activation of the nitric oxide synthase in human platelets
Giri et al., J Neurosci 2004 (Inflammation) : A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Shearer et al., Am J Physiol Endocrinol Metab 2004 : Recent studies indicate this may be due to AMPK induced phosphorylation and activation of nitric oxide synthase (NOS)
Carrasco-Chaumel et al., J Hepatol 2005 (Disease Models, Animal...) : Preconditioning or AMPK activation with aminoimidazole-4-carboxamide ribonucleoside ( AICAR ) increased AMPK and constitutive NOS activities and protected against lipid peroxidation, nitrotyrosine formation and hepatic injury in both grafts
Ropelle et al., Endocrinology 2007 (Anorexia...) : In parallel, the pharmacological activation of hypothalamic AMPK in TB animals markedly reduced the hypothalamic production of inducible nitric oxide synthase , IL-1beta, and TNF-alpha and modulated the expression of proopiomelanocortin, a hypothalamic neuropeptide that is involved in the control of energy homeostasis
Vázquez-Chantada et al., Hepatology 2009 : Because AMPK is activated by the tumor suppressor kinase LKB1, and AMPK activates endothelial nitric oxide ( NO ) synthase ( eNOS ), and NO synthesis is of great importance for hepatocyte proliferation, we hypothesized that in hepatocytes HGF may induce the phosphorylation of LKB1, AMPK, and eNOS through a process regulated by SAMe, and that this cascade might be crucial for hepatocyte growth
Lee-Young et al., J Biol Chem 2009 : Thus, AMPK regulates neuronal NOSmicro expression, NOS activity, and mitochondrial function in skeletal muscle
Bradley et al., Arterioscler Thromb Vasc Biol 2010 : Activation of AMPK by AICAR activates endothelial nitric oxide synthase in arteriolar endothelium by increasing its Ser1177 phosphorylation, which leads to vasodilation of resistance arteries and recruitment of microvascular perfusion in muscle
Centeno-Baez et al., Am J Physiol Endocrinol Metab 2011 : Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1