Gene interactions and pathways from curated databases and text-mining

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CXCR4 — PRKACB

Text-mined interactions from Literome

Masci et al., J Leukoc Biol 2003 : Of note, the ligation of CXCR4 by stromal cell derived factor-1alpha but not the engagement of CD4 by monoclonal antibody stimulates the PKA activity and induces a long lasting hyporesponsivity state in naive CD4+ lymphocytes
Hajishengallis et al., Proc Natl Acad Sci U S A 2008 (Bacteroidaceae Infections) : This is accomplished through its surface fimbriae, which induce CXCR4/TLR2 co-association in lipid rafts and interact with both receptors : Binding to CXCR4 induces cAMP dependent protein kinase A (PKA) signaling, which in turn inhibits TLR2 mediated proinflammatory and antimicrobial responses to the pathogen
Stückemann et al., Development 2012 : We show that Cxcr4a inhibits PKA activity independently of Hh signalling, and propose that Cxcr4a enhances Hh-dependent proliferation by promoting the activity of Gli1