Gene interactions and pathways from curated databases and text-mining

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BECN1 — PRKAB2

Text-mined interactions from Literome

Matsui et al., Circ Res 2007 (Myocardial Ischemia) : In contrast, autophagy during reperfusion was accompanied by upregulation of Beclin 1 but not by activation of AMPK
Wang et al., J Biol Chem 2009 : Our findings thus propose that the AMPK-MEK/ERK-TSC-mTOR pathway regulation of Beclin 1 represents different thresholds responsible for a protective or destructive autophagy
He et al., Diabetes 2013 (Diabetes Mellitus, Experimental...) : We hypothesized that AMPK induced autophagy ameliorates diabetic cardiomyopathy by inhibiting cardiomyocyte apoptosis and examined the effects of AMPK on the interaction between Beclin1 and Bcl-2, a switch between autophagy and apoptosis, in diabetic mice and high glucose treated H9c2 cardiac myoblast cells