Gene interactions and pathways from curated databases and text-mining

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IGF1 — PRKAB1

Text-mined interactions from Literome

Suzuki et al., Biochem Biophys Res Commun 2004 : We found that IGF-1 also induced AMPK-alpha subunit phosphorylation in the human normal fibroblast TIG103 cell line, but failed to do so in a human fibroblast AT2-KY cell line lacking ATM. Immunoprecipitates of ATM collected from IGF-1 stimulated cells also caused the phosphorylation of the AMPK-alpha subunit in vitro ... These results suggest that IGF-1 induces AMPK-alpha subunit phosphorylation via an ATM dependent and LKB1 independent pathway
Baumann et al., Exp Cell Res 2007 (Multiple Myeloma) : Activation of AMPK inhibited basal extracellular signal regulated kinase ( ERK ), mammalian target of rapamycin (mTOR) and P70S6 kinase ( P70S6K ) as well as AKT phosphorylation, and blocked IL-6, IGF-1 , and HS-5 stromal cell conditioned medium induced increase of cell growth ... Activation of AMPK inhibited basal extracellular signal regulated kinase ( ERK ), mammalian target of rapamycin (mTOR) and P70S6 kinase ( P70S6K ) as well as AKT phosphorylation, and blocked IL-6, IGF-1 , and HS-5 stromal cell conditioned medium induced increase of cell growth
Zhu et al., Placenta 2009 (Obesity) : The objective of this study was to assess the activity of AMPK and its role in the observed down-regulation of insulin/IGF-1 signaling in cotyledonary (COT) arteries supplying the placental component of the ewe placentome
Coyral-Castel et al., Domest Anim Endocrinol 2010 : Treatment with metformin ( 10mM ), an activator of AMPK, increased AMPK phosphorylation ( P < 0.05 ) and reduced progesterone secretion by 50 % ( P < 0.05 ) in the basal state and in response to IGF-1 or FSH in goat granulosa cells
Luo et al., Mol Cell Biochem 2011 (Colonic Neoplasms...) : IGF-1 reduced p-ATM, p-AMPK , and then p-ACCa protein levels in HCT-8 cells
Ning et al., Endocrinology 2011 (Diabetes Mellitus, Experimental...) : IGF-I dose-dependently suppressed phosphorylation of AMPK T172, and it stimulated AMPK S485 phosphorylation in vascular smooth muscle cells ( VSMC ) ... Exposure to high glucose concentrations suppressed AMPK activity and stimulated S485 phosphorylation, and IGF-I stimulated a further increase in S485 phosphorylation and AMPK T172 suppression ... We conclude that AMPK S485 phosphorylation negatively regulates AMPK activity by modulating the T172 phosphorylation response to high glucose and IGF-I
Quinn et al., Cancer prevention research (Philadelphia, Pa.) 2013 : Previously, we showed that metformin prevented tobacco carcinogen ( NNK ) -induced lung tumorigenesis in a non-diabetic mouse model, which was associated with decreased IGF-I/insulin receptor signaling but not activation of AMPK in lung tissues, as well as decreased circulating levels of IGF-I and insulin