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NOS1 — PRKAA2
Text-mined interactions from Literome
Fleming et al., Thromb Haemost 2003
:
AMP activated protein kinase (AMPK) regulates the insulin induced activation of the
nitric oxide synthase in human platelets
Giri et al., J Neurosci 2004
(Inflammation) :
A pharmacological activator of
AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR )
inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 ) and inducible
nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Shearer et al., Am J Physiol Endocrinol Metab 2004
:
Recent studies indicate this may be due to
AMPK induced phosphorylation and activation of
nitric oxide synthase (NOS)
Carrasco-Chaumel et al., J Hepatol 2005
(Disease Models, Animal...) :
Preconditioning or
AMPK activation with aminoimidazole-4-carboxamide ribonucleoside ( AICAR )
increased AMPK and
constitutive NOS activities and protected against lipid peroxidation, nitrotyrosine formation and hepatic injury in both grafts
Ropelle et al., Endocrinology 2007
(Anorexia...) :
In parallel, the pharmacological activation of hypothalamic
AMPK in TB animals markedly
reduced the hypothalamic production of inducible
nitric oxide synthase , IL-1beta, and TNF-alpha and modulated the expression of proopiomelanocortin, a hypothalamic neuropeptide that is involved in the control of energy homeostasis
Vázquez-Chantada et al., Hepatology 2009
:
Because AMPK is activated by the tumor suppressor kinase LKB1, and
AMPK activates endothelial
nitric oxide ( NO ) synthase ( eNOS ), and NO synthesis is of great importance for hepatocyte proliferation, we hypothesized that in hepatocytes HGF may induce the phosphorylation of LKB1, AMPK, and eNOS through a process regulated by SAMe, and that this cascade might be crucial for hepatocyte growth
Lee-Young et al., J Biol Chem 2009
:
Thus,
AMPK regulates neuronal NOSmicro expression,
NOS activity, and mitochondrial function in skeletal muscle
Bradley et al., Arterioscler Thromb Vasc Biol 2010
:
Activation of
AMPK by AICAR
activates endothelial
nitric oxide synthase in arteriolar endothelium by increasing its Ser1177 phosphorylation, which leads to vasodilation of resistance arteries and recruitment of microvascular perfusion in muscle
Centeno-Baez et al., Am J Physiol Endocrinol Metab 2011
:
Resveratrol inhibition of inducible
nitric oxide synthase in skeletal muscle
involves AMPK but not SIRT1