Gene interactions and pathways from curated databases and text-mining

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PARP14 — PRKAA1

Text-mined interactions from Literome

Walker et al., Biochem Biophys Res Commun 2006 : The aim of this study was to examine the role of AMPK in modulating poly ( ADP-ribose ) polymerase ( PARP ), a nuclear enzyme involved in maintaining chromatin structure and DNA repair ... These data suggest a novel role for AMPK in regulating PARP activity through a direct interaction involving phosphorylation
Li et al., Neurosci Lett 2010 (Stroke) : PolyADP ribose polymerase ( PARP ) , a key mediator of ischemic cell death, stimulates AMPK activation, yet activation of PARP appears to be selectively detrimental in male brain
Son et al., Toxicol Appl Pharmacol 2011 : Consequently, these results suggest that cadmium mediated ROS generation causes PARP activation and energy depletion, and eventually induces autophagy through the activation of LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells