Gene interactions and pathways from curated databases and text-mining

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NOS1 — PRG2

Text-mined interactions from Literome

Presle et al., Arthritis Rheum 1999 : To evaluate the effect of nitric oxide synthase (NOS) inhibitors on proteoglycan synthesis following intraarticular administration of interleukin-1beta (IL-1beta) in rats
Cipolletta et al., Br J Pharmacol 1998 (Cartilage Diseases) : When studying the effect of NOS inhibitors on proteoglycan synthesis by cartilage cells treated with IL-1beta, we observed that : ( i ) they had more marked effects on proteoglycan synthesis in chondrocytes than in cartilage samples ; ( ii ) they could be roughly classified in the following rank order of potency : L-NAME > or = L-NMMA > > AG > SMT > > AETU and ( iii ) potentiation of the IL-1 effect by AETU was consistent with cytotoxicity in the millimolar range