Gene interactions and pathways from curated databases and text-mining

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IGF2 — PRG2

Text-mined interactions from Literome

Okuda et al., Spine (Phila Pa 1976) 2001 : The present findings indicate that the age related decline in insulin-like growth factor-I dependent proteoglycan synthesis in nucleus pulposus is caused , at least in part, by the increase in insulin-like growth factor binding proteins at the early stages of aging, and further suggest that a loss of proteoglycan synthesis during the late stages of aging is caused by the downregulation of insulin-like growth factor-I receptor in addition to an increase in insulin-like growth factor binding proteins
Jin et al., Arch Biochem Biophys 2003 : In the absence of tissue shear, IGF-I augmented protein and proteoglycan synthesis up to twofold at IGF-I concentrations in the range of 100-300 ng/ml
Tesch et al., J Orthop Res 1992 : When these growth factors were added to articular cartilage explants complexed with their native serum binding proteins ( BPs ), both IGF-I-BP complex and IGF-II-BP complex stimulated proteoglycan synthesis to different degrees over a 3-day period
Mitropoulou et al., Biochimie 2004 (Breast Neoplasms) : The effect of IGF on proteoglycan ( PG ) synthesis by two human breast cancer epithelial cell lines, the ER-positive MCF-7 and the ER-negative BT-20, was studied alone and in combination with genistein
Imai et al., Acta Endocrinol (Copenh) 1992 (Eye Diseases...) : In contrast, IGF-1 stimulated secretion of small proteoglycan while PDGF had little effect on proteoglycan synthesis in skin fibroblasts
Leach et al., Domest Anim Endocrinol 2007 : In cell culture, IGF-I stimulated proteoglycan synthesis and increased the expression of Indian hedgehog (Ihh) and type X collagen, markers of chondrocyte differentiation
Abrahamsson et al., J Orthop Res 1991 : To identify factors with the potential of affecting those abilities, the effects of recombinant human insulin-like growth factor ( rhIGF-I ), insulin and fetal calf serum ( FCS ) on the synthesis of proteoglycan , collagen, and non-collagen protein and cell proliferation were investigated in short-term explant cultures of the deep flexor tendon of the rabbit
Nevo et al., Mech Ageing Dev 1984 : The effects of normal human serum, insulin-like growth factor and beta-D-xyloside on the synthesis of proteoglycan , as well as their differential effect on the synthesis of chondroitin sulfate and keratan sulfate side-chains, were studied in chick embryonal cartilage
Silbergeld et al., Acta Endocrinol (Copenh) 1981 : It was postulated that IGF could stimulate proteoglycan synthesis not only by elongating existing chondroitin sulphate chains but also by increased synthesis of other sugar chains e.g. keratan sulphate and oligosaccharides
van Beuningen et al., Ann Rheum Dis 1993 : In the presence of insulin-like growth factor no extra effect of TGF-beta on proteoglycan synthesis was observed
Takigawa et al., Endocrinology 1997 (Bone Neoplasms...) : Both insulin-like growth factor (IGF)-I and IGF-II increased the synthesis of cartilage-type, large proteoglycan in a human chondrosarcoma derived chondrocyte cell line, HCS-2/8 ... In contrast to the stimulatory effects of IGFs on costal chondrocytes of the young rabbit, the stimulatory effect of IGF-II on proteoglycan synthesis in HCS-2/8 cells was more potent than that of IGF-I ... Both anti-IGF-IR antibody and anti-IGF-II antibody inhibited proteoglycan synthesis ... Mannose-6-phosphate, which is known to bind to IGF-IIR, stimulated proteoglycan synthesis, potentiated IGF-II stimulated proteoglycan synthesis, and enhanced the binding affinity for IGF-II but not for IGF-I ... Even in the presence of anti-IGF-IR antibody, IGF-II and mannose-6-phosphate stimulated proteoglycan synthesis in the cells