Gene interactions and pathways from curated databases and text-mining

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NPY — PPY

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Parker et al., Peptides 2001 : The PP/NPY and Y4 receptors are also selectively blocked by human or rat pancreatic polypeptide (PP) and the blocking peptides are not dissociated by high concentrations of alkali chlorides ( which restore most of the binding of subtype-selective agonists to Y1 and Y2 sites )
Feth et al., Br J Pharmacol 1992 (Leukemia, Erythroblastic, Acute) : NPY13-36 , vasoactive intestinal peptide (VIP) and pancreatic polypeptide (PP) increased intracellular Ca2+ only poorly
Acuna-Goycolea et al., J Neurosci 2005 (Synaptic Transmission) : Mechanisms of neuropeptide Y , peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus
Schlicker et al., Naunyn Schmiedebergs Arch Pharmacol 1991 : The present results suggest that NPY inhibits serotonin release in the rat brain via presynaptic NPY receptors, which are also activated by PYY and pancreatic polypeptide and may be negatively coupled to an adenylate cyclase
Balasubramaniam et al., Peptides 1990 : Peptides unrelated to NPY did not compete with 125I-NPY for the binding sites even at 1 microM concentrations, whereas homologous peptides, peptide YY (PYY) and pancreatic polypeptide (PP) , and NPY ( 13-36 ) inhibited 125I-NPY binding but with lower potency compared to NPY