Gene interactions and pathways from curated databases and text-mining

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MAPK14 — PPP2R1A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Lee et al., J Cell Physiol 2003 : Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain ... Taken together, our result suggests that PP2A plays a regulatory role in p38 MAPK activation in endothelial cells exposed to cyclic strain
Liu et al., Am J Physiol Heart Circ Physiol 2003 (Translocation, Genetic) : We found that N6-cyclopentyladenosine ( CPA ; an adenosine A1 receptor agonist ) -induced PP2a translocation was blocked by p38 MAPK inhibition but not by JNK inhibition
Liu et al., Am J Physiol Heart Circ Physiol 2004 (MAP Kinase Signaling System) : We also found that PP2A coimmunoprecipitated with ERK and MAPK/ERK (MEK) in cardiac ventricular myocytes, and H ( 2 ) O ( 2 ) increased the ERK associated PP2A activity that was blocked by inhibition of p38 MAPK
Boudreau et al., J Leukoc Biol 2004 (MAP Kinase Signaling System) : Regulation of p38 MAPK by PP2A was demonstrated, as OA treatment caused a dose dependent increase in p38 MAPK phosphorylation
Hersch et al., Am J Physiol Cell Physiol 2004 : In contrast, ETB initiates an inhibitory pathway involving p38 MAPK dependent activation of PP2A that causes dephosphorylation of CPI-17
Boudreau et al., Cell Signal 2007 (Leukemia, T-Cell) : Moreover, OA treatment caused p38 MAPK to be phosphorylated in a dose- and time dependent fashion, indicating that PP2A prevented p38 MAPK activation
Brust et al., J Neurosci 2006 (Synaptic Transmission) : Phospho-p38 MAPK activation by A1 receptor stimulation induced translocation of PP2a ( protein phosphatase 2a ) to the membrane
Prickett et al., Mol Cell Biol 2007 : The results show that alpha-4 targets PP2A activity to MEK3 to suppress p38 MAPK activation by cytokines, thereby inhibiting apoptosis and anoikis
Yoon et al., Mol Cancer Res 2009 (MAP Kinase Signaling System) : Small interfering RNA targeting of PP2A effectively attenuated sphingosine induced p38 MAPK activation through restoration of ERK activity, suggesting PP2A mediated opposing regulation of ERK and p38 MAPK
Amorim et al., J Neurosci Res 2010 : These findings suggest that the regulation of the phosphorylation of PP2A and PTEN may be involved in the effects of progesterone on the phosphorylation of Tau and on the activity of phophoinositide-3 kinase and mitogen activated protein kinase in the brain
Liu et al., Glia 2012 (Alzheimer Disease) : Activation of PP2A promotes actin organization and inhibits p38 mitogen activated protein kinases ( p38 MAPK ), while simultaneous activation of p38 MAPK partially abolishes the PP2A induced astrocytes migration
Law et al., International journal of molecular sciences 2013 : However, H9N2/G1 did not induce the expression of PP2A indicating that the activation of PP2A is not mediated by p38MAPK in virus infected PBMac