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PPP1R1B — PRKAR2A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Edwards et al., Alcohol Clin Exp Res 2002
:
We measured the
protein kinase A (PKA) mediated phosphorylation of
DARPP-32 and the NR1 subunit of the NMDA receptor ... SKF82958 alone significantly increased
PKA mediated phosphorylation of both
DARPP-32 and NR1 ... However, when D1 receptors were blocked, bromocriptine reduced the
PKA mediated phosphorylation of both
DARPP-32 and NR1
Andersson et al., J Neurosci 2005
(Catalepsy) :
Our data indicate that a considerable proportion of the psychomotor effect of cannabinoids can be accounted for by a signaling cascade in striatal projection neurons involving
PKA dependent phosphorylation of
DARPP-32 , achieved via modulation of dopamine D2 and adenosine A2A transmission
Borgkvist et al., Neuropharmacology 2008
:
These results indicate that, in the striatum, THC promotes
PKA dependent phosphorylation of
DARPP-32 in striatal medium spiny neurons expressing dopamine D1 and adenosine A2A receptors
Honjo et al., Clin Neuropathol 2008
(Multiple System Atrophy) :
DARPP32 has been identified as a
target for dopamine and
PKA in the striatum
Bertran-Gonzalez et al., Biol Psychiatry 2009
:
Thus, blockade of D2Rs promotes histone H3 phosphorylation through the A2AR mediated activation of Galpha ( olf ) and inhibition of protein phosphatase-1 (PP-1) through the
PKA dependent phosphorylation of
DARPP-32
Santini et al., PloS one 2010
(Dyskinesias...) :
We here studied, in the gold-standard non-human primate model of Parkinson 's disease, the changes in
PKA dependent phosphorylation of
DARPP-32 and GluR1 AMPA receptor, as well as in ERK and ribosomal protein S6 ( S6 ) phosphorylation, associated to acute and chronic administration of L-DOPA
Bonito-Oliva et al., Neuropharmacology 2013
:
They also indicate that this effect is exerted by suppressing dephosphorylation at Ser240/244, through
PKA dependent activation of
DARPP-32 and inhibition of PP-1