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PPARGC1A — SIRT7

Text-mined interactions from Literome

Amat et al., J Biol Chem 2009 : Conversely, SIRT1 activation or overexpression in differentiated C2C12 myotubes increased PGC-1alpha mRNA expression
Goh et al., Curr Diabetes Rev 2010 (Diabetes Mellitus, Type 2...) : At the molecular forefront, energy sensing signaling pathways in T2DM, such as PGC1alpha, AMPK, O-GlcNAc and most recently SIRT1 have been shown to play key roles in oxidative stress, mitochondrial dysfunction, inflammation and glucolipotoxicity, which are the hallmarks of insulin resistance and T2DM, Furthermore, SIRT1 , PGC1alpha and O-GlcNAc also regulate gene expression and may play a role in the epigenetic machinery, thus providing an explanation to how metabolism switches to either a ` thrift ' or ` spend ' mode depending on food availability